Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 13/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10845633 | 0.83 | TYMS (0.58) | PDE2APDE10ARXFP1LMNASMN1; SMN2 | |
| SCHEMBL14054782 | 0.78 | PDE2A (0.67) | PDE2APDE10AMEN1KMT2APOLB | |
| SCHEMBL10845582 | 0.77 | KMT2A (0.56) | RXFP1LMNASMN1; SMN2HIF1AMEN1 | |
| SCHEMBL10847230 | 0.77 | ALOX15 (0.58) | LMNASMN1; SMN2HIF1AMEN1KMT2A | |
| SCHEMBL14764776 | 0.76 | TYMS (0.70) | PDE2APDE10AMEN1KMT2APOLB | |
| SCHEMBL14054628 | 0.75 | PDE2A (0.68) | PDE2APDE10A | |
| SCHEMBL20440616 | 0.74 | BRD4 (0.52) | PDE2APDE10A | |
| SCHEMBL12070874 | 0.73 | KDM4E (0.64) | LMNASMN1; SMN2HIF1AMEN1KMT2A | |
| SCHEMBL21642413 | 0.73 | LMNA (0.37) | PDE2APDE10ARXFP1LMNASMN1; SMN2 | |
| SCHEMBL14765127 | 0.73 | PDE2A (0.53) | PDE2APDE10APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | claimed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |