Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | RGS12 | O14924 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2050404 | 0.83 | GAA (0.73) | KDM4EHPGDHSD17B10GAATSHR | |
| SCHEMBL4023960 | 0.77 | ESR1 (0.61) | KDM4EHPGDHSD17B10GAATSHR | |
| SCHEMBL4066457 | 0.77 | HPGD (0.68) | KDM4EHPGDHSD17B10GAATSHR | |
| SCHEMBL30523685 | 0.77 | HPGD (0.68) | KDM4EHPGDHSD17B10GAATSHR | |
| SCHEMBL1362192 | 0.77 | HPGD (0.68) | KDM4EHPGDHSD17B10GAATSHR | |
| SCHEMBL2332010 | 0.76 | SLC22A12 (0.44) | KDM4EHPGDHSD17B10GAATSHR | |
| SCHEMBL8277240 | 0.74 | CA2 (0.62) | KDM4EHPGDHSD17B10GAATSHR | |
| SCHEMBL3491000 | 0.74 | KDM4E (0.63) | KDM4EHPGDHSD17B10GAATSHR | |
| SCHEMBL15499985 | 0.74 | KDM4E (0.58) | KDM4EHPGDHSD17B10GAATSHR | |
| SCHEMBL14768432 | 0.73 | ALDH1A1 (0.56) | TDP1LMNAALDH1A1KMT2APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034756-A1 | BIPHENYL COMPOUNDS FOR USE IN TREATING MALARIA AND OTHER PARASITIC DISORDERS | MEDIZINISCHE HOCHSCHULE HANNOVER (DE) | 2013-03-14 | — | — | WO | disclosed |