Sugi Predict

Sugi Predict / Compounds / SCHEMBL2332010

SCHEMBL2332010

SCHEMBL2332010

CC(=O)Cc1ccc(C)c(CC(=O)O)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC22A12 Q96S37 2/20 0.44
▸ GAA P10253 4/20 0.43
▸ KDM4E B2RXH2 4/20 0.43
▸ HPGD P15428 4/20 0.43
▸ HSD17B10 Q99714 4/20 0.43
▸ MAPT P10636 3/20 0.43
▸ TSHR P16473 3/20 0.43
▸ NFKB1 P19838 2/20 0.43
▸ TDP1 Q9NUW8 2/20 0.43
▸ POLB P06746 2/20 0.43
▸ RGS12 O14924 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ APEX1 P27695 1/20 0.43
▸ THPO P40225 1/20 0.43
▸ BLM P54132 1/20 0.43
▸ GNAI1 P63096 1/20 0.43
▸ PMP22 Q01453 1/20 0.43
▸ HIF1A Q16665 1/20 0.43
▸ ALDH1A1 P00352 4/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7789892 0.91 POLB (0.42) SLC22A12GAAKDM4EHPGDHSD17B10
SCHEMBL210161 0.85 PKM (0.42) SLC22A12GAAHPGDMAPTPOLB
Toluene SCHEMBL8907280 0.85 L3MBTL1 (0.41) SLC22A12GAAMAPTTDP1POLB
Toluene SCHEMBL1159746 0.85 L3MBTL1 (0.41) SLC22A12GAAMAPTTDP1POLB
Toluene SCHEMBL1079482 0.85 L3MBTL1 (0.41) SLC22A12GAAMAPTTDP1POLB
Toluene SCHEMBL8994440 0.85 L3MBTL1 (0.41) SLC22A12GAAMAPTTDP1POLB
SCHEMBL17424894 0.84 SMN1; SMN2 (0.45) SLC22A12GAAKDM4EHPGDHSD17B10
SCHEMBL658608 0.84 KLKB1 (0.43) SLC22A12GAAKDM4EHPGDHSD17B10
SCHEMBL20045097 0.81 HPGD (0.50) SLC22A12GAAKDM4EHPGDHSD17B10
SCHEMBL1223549 0.81 CYP4F2 (0.42) SLC22A12GAAKDM4EHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106243006-B (3-alkylthio) acrylic acid derivative compound and cosmetic application thereof 爱西美有限公司 2019-12-31 — — CN disclosed
US-9815783-B2 (3-alkylthio)propenoic acid-derived compounds and their application in cosmetics EXSYMOL (MC) 2017-11-14 — — US disclosed
CN-106243006-A (3 alkylthio group) acrylic acid derivative compound and cosmetic applications thereof 爱西美有限公司 2016-12-21 — — CN disclosed
US-20160362364-A1 (3-ALKYLTHIO)PROPENOIC ACID-DERIVED COMPOUNDS AND THEIR APPLICATION IN COSMETICS EXSYMOL (MC) 2016-12-15 — — US disclosed
US-8003686-B2 Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives DSM IP ASSETS B.V. (NL) 2011-08-23 — — US disclosed
EP-2356986-A1 COMPOSITION FOR TREATMENT OF METABOLIC SYNDROME Universitat Rovira I Virgili (ES) 2011-08-17 — — EP disclosed
US-20100010232-A1 Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives DSM IP ASSETS B.V. (NL) 2010-01-14 — — US disclosed
US-6121512-A NUCLEOTIDE SEQUENCES WHICH CODE ENZYMATIC PROTEINS: FOR AMPLIFIED ABILITY OF PLANTS TO METABOLIZE PHENYLUREA COMPOUNDS NORTH CAROLINA STATE UNIVERSITY (US) 2000-09-19 — — US disclosed
US-6117885-A Biphenyl-substituted quinoline derivatives E. R. SQUIBB & SONS, INC. (US) 2000-09-12 — — US disclosed
WO-1999019493-A9 CYTOCHROME P-450 CONSTRUCTS AND METHODS OF PRODUCING HERBICIDE-RESISTANT TRANSGENIC PLANTS UNIV NORTH CAROLINA STATE (US) 1999-08-05 — — WO disclosed
US-5374615-A Treating hypertension and congestive heart failure, preventing cardiac hypertrophy E. R. SQUIBB & SONS, INC. (US) 1994-12-20 — — US disclosed
US-5312975-A Process for the preparation of 5-(2,4-difluorophenyl)-salicylic acid ZAMBON GROUP S.P.A. (IT) 1994-05-17 — — US disclosed
EP-0556060-A1 Biphenyl-substituted quinoline and naphthyridines derivatives as angiotensine II antagonists E.R. SQUIBB & SONS, INC. (US) 1993-08-18 — — EP disclosed
US-5225421-A Leukotriene antagonists; cytoprotective agents MERCK FROSST CANADA, INC. (CA) 1993-07-06 — — US disclosed
EP-0501269-A1 Imidazole and benzimidazole derivatives E.R. SQUIBB & SONS, INC. (US) 1992-09-02 — — EP disclosed
EP-0494419-A2 Process for the preparation of 5-(2,4-difluorophenyl)-salicylic acid ZAMBON GROUP S.p.A. (IT) 1992-07-15 — — EP disclosed
EP-0488532-A1 Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives E.R. Squibb & Sons, Inc. (US) 1992-06-03 — — EP disclosed
EP-0275667-B1 3-HETERO-SUBSTITUTED-N-BENZYL-INDOLES MERCK FROSST CANADA INC. (CA) 1992-03-18 — — EP disclosed
US-5081138-A Antiasthmatic, antiallergic, antiinflammatory and cytoprotective agents MERCK FROSST CANADA, INC. (CA) 1992-01-14 — — US disclosed
EP-0200960-A1 Total estriol fluorescence polarization immunoassay ABBOTT LABORATORIES (US) 1986-11-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100010232-A1 Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives AADAC, ARNT, PIGS SLC22A12 1830/4885GAA 2782/4885KDM4E 124/4885
US-20160362364-A1 (3-ALKYLTHIO)PROPENOIC ACID-DERIVED COMPOUNDS AND THEIR APPLICATION IN COSMETICS ALOX12, ALOX15B, ALOX15 SLC22A12 4218/4885GAA 3290/4885KDM4E 1961/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.