SCHEMBL14770554

SCHEMBL14770554

c1ccc2c(c1)c1ccccc1n2-c1cncc(-c2ccc3oc4ccc(-n5c6ccccc6c6ccccc65)cc4c3c2)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.36
ATM Q13315 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
BTK Q06187 3/20 0.34
PIK3CD O00329 2/20 0.34
PIK3CA P42336 2/20 0.34
PIK3CB P42338 2/20 0.34
PIK3CG P48736 2/20 0.34
PIK3R1 P27986 1/20 0.34
MTOR P42345 1/20 0.34
MEN1 O00255 1/20 0.32
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
RAB9A P51151 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
LRRK2 Q5S007 1/20 0.32
PLA2G2A P14555 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10041333 0.95 KDM4E (0.38) KDM4EATML3MBTL1BTKPIK3CD
SCHEMBL14770700 0.94 PLA2G2A (0.36) KDM4EATML3MBTL1BTKPIK3CD
SCHEMBL14770684 0.94 PLA2G2A (0.36) KDM4EATML3MBTL1BTKPIK3CD
SCHEMBL14770681 0.94 PLA2G2A (0.36) KDM4EATML3MBTL1BTKPIK3CD
SCHEMBL14770592 0.94 KDM4E (0.38) KDM4EATML3MBTL1BTKPIK3CD
SCHEMBL14770564 0.93 MAOA (0.37) KDM4EATML3MBTL1BTKPIK3CD
SCHEMBL14770567 0.93 MAOA (0.37) KDM4EATML3MBTL1BTKPIK3CD
SCHEMBL14770572 0.93 BTK (0.35) KDM4EATML3MBTL1BTKPIK3CD
SCHEMBL14770664 0.93 KDM4E (0.34) KDM4EATML3MBTL1BTKPIK3CD
SCHEMBL14770662 0.93 BTK (0.38) KDM4EATML3MBTL1BTKPIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9842996-B2 Amine compound having hetero-fused ring and organic electroluminescent element using amine compound IDEMITSU KOSAN CO., LTD. (JP) 2017-12-12 US disclosed
US-9842996-B2 Amine compound having hetero-fused ring and organic electroluminescent element using amine compound IDEMITSU KOSAN CO., LTD. (JP) 2017-12-12 US disclosed
US-9604972-B2 Nitrogen-containing heteroaromatic ring compound IDEMITSU KOSAN CO., LTD. (JP) 2017-03-28 US disclosed
US-9604972-B2 Nitrogen-containing heteroaromatic ring compound IDEMITSU KOSAN CO., LTD. (JP) 2017-03-28 US disclosed
US-20160163996-A1 COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME IDEMITSU KOSAN CO., LTD. (JP) 2016-06-09 US disclosed
US-20160163996-A1 COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME IDEMITSU KOSAN CO., LTD. (JP) 2016-06-09 US disclosed
US-20160013419-A1 AMINE COMPOUND HAVING HETERO-FUSED RING AND ORGANIC ELECTROLUMINESCENT ELEMENT USING AMINE COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2016-01-14 US disclosed
US-20160013419-A1 AMINE COMPOUND HAVING HETERO-FUSED RING AND ORGANIC ELECTROLUMINESCENT ELEMENT USING AMINE COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2016-01-14 US disclosed
US-20130062597-A1 NITROGEN-CONTAINING HETEROAROMATIC RING COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2013-03-14 US disclosed
US-20130062597-A1 NITROGEN-CONTAINING HETEROAROMATIC RING COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2013-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160013419-A1 AMINE COMPOUND HAVING HETERO-FUSED RING AND ORGANIC ELECTROLUMINESCENT ELEMENT USING AMINE COMPOUND CTCF, SAT1, TEAD2 KDM4E 942/4885ATM 1817/4885L3MBTL1 2674/4885
US-20130062597-A1 NITROGEN-CONTAINING HETEROAROMATIC RING COMPOUND TDO2, AHR, NOC2L KDM4E 1763/4885ATM 1105/4885L3MBTL1 3163/4885
US-20160163996-A1 COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME LEF1, PIEZO1, EPCAM KDM4E 2661/4885ATM 3988/4885L3MBTL1 1590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.