SCHEMBL14770591

SCHEMBL14770591

c1cc(-c2ccc3oc4ccc(-c5cncc(-n6c7ccccc7c7ccccc76)c5)cc4c3c2)nc(-n2c3ccccc3c3ccccc32)c1

nearest known ligand 0.32

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
IRAK4 Q9NWZ3 1/20 0.32
CASP3 P42574 1/20 0.31
SENP7 Q9BQF6 1/20 0.31
SENP6 Q9GZR1 1/20 0.31
PTPRF P10586 4/20 0.31
PTPN2 P17706 4/20 0.31
PTPN1 P18031 4/20 0.31
PLA2G10 O15496 1/20 0.31
PLA2G2A P14555 1/20 0.31
PLA2G4A P47712 1/20 0.31
PGR P06401 1/20 0.30
KDM4E B2RXH2 1/20 0.30
ATM Q13315 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14770593 0.91 CASP3 (0.34) CASP3SENP7SENP6PLA2G10PLA2G2A
SCHEMBL14770562 0.87 PTPRF (0.35) CASP3SENP7SENP6PTPRFPTPN2
SCHEMBL20706680 0.86 CASP3 (0.38) CASP3SENP7SENP6PTPRFPTPN2
SCHEMBL14770592 0.85 KDM4E (0.38) PLA2G10PLA2G2APLA2G4APGRKDM4E
SCHEMBL14770637 0.84 PTPRF (0.34) CASP3SENP7SENP6PTPRFPTPN2
SCHEMBL14770599 0.84 PLA2G2A (0.41) CASP3SENP7SENP6PTPRFPTPN2
SCHEMBL14770602 0.84 PLA2G2A (0.39) CASP3SENP7SENP6PLA2G10PLA2G2A
SCHEMBL14770554 0.84 KDM4E (0.36) CASP3SENP7SENP6PLA2G10PLA2G2A
SCHEMBL18158874 0.84 KDM4E (0.39) CASP3SENP7SENP6PTPRFPTPN2
SCHEMBL14770625 0.83 MKNK1 (0.33) CASP3SENP7SENP6PTPRFPTPN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9604972-B2 Nitrogen-containing heteroaromatic ring compound IDEMITSU KOSAN CO., LTD. (JP) 2017-03-28 US disclosed
US-9604972-B2 Nitrogen-containing heteroaromatic ring compound IDEMITSU KOSAN CO., LTD. (JP) 2017-03-28 US disclosed
US-20130062597-A1 NITROGEN-CONTAINING HETEROAROMATIC RING COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2013-03-14 US disclosed
US-20130062597-A1 NITROGEN-CONTAINING HETEROAROMATIC RING COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2013-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130062597-A1 NITROGEN-CONTAINING HETEROAROMATIC RING COMPOUND TDO2, AHR, NOC2L IRAK4 4039/4885CASP3 2891/4885SENP7 4417/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.