Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.34 |
| ▸ | KDM1A | O60341 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CCKAR | P32238 | 1/20 | 0.33 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12649024 | 0.89 | MALT1 (0.39) | MALT1MGLLMEN1KMT2AMAPT | |
| SCHEMBL1764920 | 0.87 | MEN1 (0.43) | MALT1MEN1KMT2AMAPTPTGS2 | |
| SCHEMBL14780898 | 0.87 | MGLL (0.40) | MGLLPTGS2CCKAR | |
| SCHEMBL1765378 | 0.84 | CCKAR (0.46) | MALT1MGLLMEN1KMT2AMAPT | |
| SCHEMBL12649166 | 0.84 | RPA1 (0.47) | MGLLPTGS2CCKAR | |
| SCHEMBL14780897 | 0.83 | CCKAR (0.49) | MGLLPTGS2CCKAR | |
| SCHEMBL1526038 | 0.79 | MEN1 (0.45) | MALT1MEN1KMT2AMAPTPTGS2 | |
| SCHEMBL29397883 | 0.79 | MEN1 (0.45) | MALT1MEN1KMT2AMAPTPTGS2 | |
| SCHEMBL15004266 | 0.78 | MALT1 (0.41) | MALT1MGLLMEN1KMT2AMAPT | |
| SCHEMBL1765529 | 0.78 | PPP1CA (0.47) | MALT1MGLLMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399682-B2 | Substituted (pyrazolylcarbonyl)imidazolidinones and their use | AICURIS GMBH & CO. KG (DE) | 2013-03-19 | — | — | US | disclosed |