Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.39 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.39 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.39 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14780924 | 0.86 | GPR119 (0.63) | GPR119USP2ALDH1A1L3MBTL1HPGD | |
| SCHEMBL14780934 | 0.82 | USP2 (0.60) | GPR119USP2ALDH1A1L3MBTL1HPGD | |
| SCHEMBL3487761 | 0.76 | GPR119 (0.82) | GPR119ALDH1A1MAPT | |
| SCHEMBL4555361 | 0.74 | GPR119 (0.66) | GPR119USP2ALDH1A1L3MBTL1HPGD | |
| SCHEMBL14780920 | 0.73 | ITGB3 (0.50) | GPR119MAPT | |
| SCHEMBL13654718 | 0.72 | ALDH1A1 (0.63) | USP2ALDH1A1L3MBTL1HPGDALOX15 | |
| SCHEMBL14960276 | 0.72 | MAPT (0.40) | GPR119ALDH1A1L3MBTL1ALOX15MAPT | |
| SCHEMBL13506522 | 0.70 | USP2 (0.64) | GPR119USP2ALDH1A1L3MBTL1HPGD | |
| SCHEMBL4299026 | 0.70 | ALDH1A1 (0.57) | USP2ALDH1A1F2PRSS1PRSS2 | |
| SCHEMBL15285555 | 0.70 | ALDH1A1 (0.68) | USP2ALDH1A1L3MBTL1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399485-B2 | Acyl bipiperidinyl compounds useful as GPR 119 agonists | MERCK SHARP & DOHME CORP. (US) | 2013-03-19 | — | — | US | disclosed |