Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 6/20 | 0.39 |
| ▸ | CA2 | P00918 | 6/20 | 0.39 |
| ▸ | CA9 | Q16790 | 6/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 3/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1814092 | 0.89 | KDM4E (0.44) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL30545643 | 0.84 | CNR2 (0.42) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL7475416 | 0.84 | CNR2 (0.42) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL2032625 | 0.84 | CA1 (0.56) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL3622568 | 0.84 | LPL (0.41) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL30242746 | 0.84 | CA1 (0.56) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL1437728 | 0.82 | ALDH1A1 (0.41) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL310685 | 0.82 | NOTUM (0.47) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL10209953 | 0.82 | ATAD2 (0.42) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL8444503 | 0.82 | KDM4E (0.39) | KDM4EALDH1A1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570407-A1 | Tetrazole-substituted arylamide derivatives and their use as P2x3 and/or P2x2/3 purinergic receptor antagonists | F. Hoffmann-La Roche AG (CH) | 2013-03-20 | — | — | EP | disclosed |