Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | MC5R | P33032 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11116252 | 0.82 | HDAC8 (0.48) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9115641 | 0.77 | MMP2 (0.41) | LMNAKDM4EALDH1A1MAPTLTA4H | |
| SCHEMBL3103938 | 0.76 | KMT2A (0.54) | LMNADRD2DRD3GAAKDM4E | |
| SCHEMBL9371365 | 0.74 | CYP1A1 (0.56) | LMNADRD2DRD3GAAKDM4E | |
| SCHEMBL731316 | 0.72 | METAP2 (0.50) | RAB9ANPC1HDAC3HDAC4HDAC1 | |
| SCHEMBL13485803 | 0.72 | RAB9A (0.61) | LMNADRD2DRD3GAAKDM4E | |
| SCHEMBL2747220 | 0.72 | PLK1 (0.60) | LMNADRD2DRD3GAAKDM4E | |
| SCHEMBL1671110 | 0.70 | CYP1A1 (0.64) | LMNADRD2DRD3GAAKDM4E | |
| SCHEMBL11341261 | 0.70 | KDM4E (0.54) | GAAKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11136366 | 0.70 | HDAC8 (0.50) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7914780-B1 | Aminopeptidase A (APA) targeting peptides for the treatment of cancer | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-03-29 | — | — | US | disclosed |
| US-7420030-B2 | Aminopeptidase A (APA) targeting peptides for the treatment of cancer | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2008-09-02 | — | — | US | disclosed |
| US-20050003466-A1 | Aminopeptidase a (APA) targeting peptides for the treatment of cancer | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-01-06 | — | — | US | disclosed |