Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14782692 | 0.87 | ALDH1A1 (0.45) | LMNAHPGDTSHREPHX2ALDH1A1 | |
| SCHEMBL14782977 | 0.87 | HPGD (0.55) | LMNAHPGDTSHREPHX2ALDH1A1 | |
| SCHEMBL14782827 | 0.85 | ERCC1 (0.53) | LMNAHPGDTSHREPHX2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL25251752 | 0.81 | HPGD (0.49) | LMNAHPGDTSHREPHX2ALDH1A1 | |
| SCHEMBL14782775 | 0.80 | PKM (0.55) | LMNAHPGDTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL8278937 | 0.74 | MAPT (0.50) | LMNAHPGDALDH1A1POLBNPC1 | |
| SCHEMBL14979286 | 0.74 | HPGD (0.44) | LMNAHPGDTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL14782772 | 0.73 | ERCC1 (0.52) | LMNAHPGDEPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL30491752 | 0.73 | ERCC1 (0.52) | LMNAHPGDEPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL14783152 | 0.72 | LMNA (0.55) | LMNAHPGDTSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013038308-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-03-21 | — | — | WO | disclosed |