Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NMT1 | P30419 | 2/20 | 0.46 |
| ▸ | CCKAR | P32238 | 3/20 | 0.45 |
| ▸ | MGLL | Q99685 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | NMT2 | O60551 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14783422 | 0.96 | NMT1 (0.47) | MAPTAKR1C3SLC6A7MEN1HSP90AA1 | |
| SCHEMBL14784083 | 0.89 | RAB9A (0.49) | MAPTMEN1HSP90AA1KMT2AALDH1A1 | |
| SCHEMBL14784224 | 0.83 | MET (0.52) | AKR1C3NMT1KDM4EALDH1A1NMT2 | |
| SCHEMBL14783745 | 0.83 | ADAMTS5 (0.46) | MAPTMEN1HSP90AA1KMT2ANMT1 | |
| SCHEMBL17061423 | 0.83 | F10 (0.46) | MAPTMEN1HSP90AA1KMT2ANMT1 | |
| SCHEMBL14783723 | 0.82 | HTR3A (0.56) | MAPTKMT2ANPC1RAB9APRMT5 | |
| SCHEMBL6415146 | 0.82 | SLC6A7 (0.50) | MAPTSLC6A7KMT2AKDM4EALDH1A1 | |
| SCHEMBL14784551 | 0.81 | MEN1 (0.45) | MEN1HSP90AA1KMT2ANMT1NMT2 | |
| SCHEMBL14783746 | 0.81 | CACNA1B (0.46) | MAPTMEN1HSP90AA1KMT2ANMT1 | |
| SCHEMBL14783548 | 0.80 | HRH3 (0.56) | PDE3BPDE3APRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755976-B1 | 6-SUBSTITUTED 3-(QUINOLIN-6-YLTHIO)-[1,2,4]TRIAZOLO[4,3-A]PYRIDINES AS C-MET TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2018-07-18 | — | — | EP | disclosed |
| US-9474762-B2 | Triazolopyridine compounds | NOVARTIS AG (CH) | 2016-10-25 | — | — | US | disclosed |
| US-20150250799-A1 | Triazolopyridine Compounds | NOVARTIS AG (CH) | 2015-09-10 | — | — | US | disclosed |
| US-9062045-B2 | Triazolopyridine compounds | NOVARTIS AG (CH) | 2015-06-23 | — | — | US | disclosed |
| EP-2755976-A1 | 6 - SUBSTITUTED 3 - (QUINOLIN- 6 - YLTHIO) - [1,2,4]TRIAZOLO [4, 3 -A]PYRADINES AS TYROSINE KINASE | Novartis AG (CH) | 2014-07-23 | — | — | EP | disclosed |
| US-20130245002-A1 | Triazolopyridine Compounds | NOVARTIS AG (CH) | 2013-09-19 | — | — | US | disclosed |
| WO-2013038362-A1 | 6 - SUBSTITUTED 3 - (QUINOLIN- 6 - YLTHIO) - [1,2,4] TRIAZOLO [4, 3 -A] PYRADINES AS TYROSINE KINASE | NOVARTIS AG (CH) | 2013-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150250799-A1 | Triazolopyridine Compounds | FLT3, RET, MET | MAPT 1866/4885AKR1C3 2950/4885SLC6A7 2449/4885 |
| US-20130245002-A1 | Triazolopyridine Compounds | FLT3, RET, MET | MAPT 1866/4885AKR1C3 2950/4885SLC6A7 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.