SCHEMBL1479567

SCHEMBL1479567

C[Si](C)(C)OC(=O)c1ccc(CN2[Si](C)(C)CC[Si]2(C)C)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.38
RAB9A P51151 3/20 0.37
GAA P10253 2/20 0.37
SMN1; SMN2 Q16637 5/20 0.36
MAPK1 P28482 2/20 0.36
RECQL P46063 2/20 0.36
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
MAPT P10636 2/20 0.36
MEN1 O00255 1/20 0.36
USP2 O75604 1/20 0.36
POLB P06746 1/20 0.36
THRB P10828 1/20 0.36
NR4A1 P22736 1/20 0.36
APEX1 P27695 1/20 0.36
APOBEC3A P31941 1/20 0.36
KMT2A Q03164 1/20 0.36
HIF1A Q16665 1/20 0.36
APOBEC3G Q9HC16 1/20 0.36
TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1479787 0.83
SCHEMBL1477947 0.81 CHKA (0.37) FAAHRAB9AGAASMN1; SMN2MAPK1
SCHEMBL1478409 0.78 ALDH1A1 (0.37) RAB9ASMN1; SMN2KDM4EALDH1A1MAPT
SCHEMBL8460883 0.74 CA1 (0.44) GAAMAPK1KDM4EALDH1A1MAPT
SCHEMBL1478087 0.70 ALDH1A1 (0.34) RAB9ASMN1; SMN2ALDH1A1MAPTUSP2
SCHEMBL1478927 0.69 LOXL2 (0.40) RAB9AGAASMN1; SMN2MAPK1KDM4E
SCHEMBL11091381 0.69 ALDH1A1 (0.50) RAB9AGAASMN1; SMN2ALDH1A1MAPT
SCHEMBL12212913 0.69 PDCD1 (0.46) RAB9AGAASMN1; SMN2KDM4EALDH1A1
SCHEMBL10917868 0.67 HPGD (0.54) SMN1; SMN2ALDH1A1MAPTKMT2ATSHR
SCHEMBL10931509 0.67 CA12 (0.59) RAB9AGAASMN1; SMN2MAPK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US claimed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US claimed
EP-2699606-B1 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORP (JP) 2016-09-28 EP disclosed
US-9403919-B2 Polymers functionalized with a carboxylic or thiocarboxylic ester containing a silylated amino group BRIDGESTONE CORPORATION (JP) 2016-08-02 US disclosed
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US disclosed
EP-2699606-A2 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP Bridgestone Corporation (JP) 2014-02-26 EP disclosed
EP-2483317-B1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2014-02-26 EP disclosed
US-20140018500-A1 Polymers Functionalized With A Carboxylic Or Thiocarboxylic Ester Containing A Silylated Amino Group BRIDGESTONE CORPORATION (JP) 2014-01-16 US disclosed
WO-2012135451-A2 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-10-04 WO disclosed
EP-2483317-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-08-08 EP disclosed
US-20120184677-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2012-07-19 US disclosed
WO-2011041534-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-04-07 WO disclosed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US disclosed