SCHEMBL1477947

SCHEMBL1477947

C[Si](C)(C)OC(=O)c1ccc(CN2CCC[Si]2(C)C)cc1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHKA P35790 1/20 0.37
MAPK1 P28482 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
FAAH O00519 1/20 0.35
RAB9A P51151 3/20 0.34
GAA P10253 1/20 0.34
HRH3 Q9Y5N1 3/20 0.34
LMNA P02545 2/20 0.34
KDM4E B2RXH2 1/20 0.34
NPC1 O15118 1/20 0.34
HTT P42858 1/20 0.34
MAPT P10636 1/20 0.34
TSHR P16473 1/20 0.34
STAT3 P40763 1/20 0.34
SIRT1 Q96EB6 1/20 0.34
KMT2A Q03164 1/20 0.34
HDAC1 Q13547 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1479508 0.85
SCHEMBL1479567 0.81 FAAH (0.38) CHKAMAPK1SMN1; SMN2FAAHRAB9A
SCHEMBL1478087 0.77 ALDH1A1 (0.34) SMN1; SMN2RAB9ANPC1HTTMAPT
SCHEMBL8761511 0.71 SIGMAR1 (0.45) LMNA
SCHEMBL1478409 0.71 ALDH1A1 (0.37) SMN1; SMN2RAB9AKDM4ENPC1HTT
SCHEMBL31042761 0.70
SCHEMBL8460883 0.70 CA1 (0.44) MAPK1GAALMNAKDM4EMAPT
SCHEMBL1478558 0.66 SMN1; SMN2 (0.30) SMN1; SMN2
SCHEMBL1478927 0.65 LOXL2 (0.40) MAPK1SMN1; SMN2RAB9AGAAKDM4E
SCHEMBL11091381 0.65 ALDH1A1 (0.50) SMN1; SMN2RAB9AGAANPC1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US claimed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US claimed
EP-2699606-B1 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORP (JP) 2016-09-28 EP disclosed
US-9403919-B2 Polymers functionalized with a carboxylic or thiocarboxylic ester containing a silylated amino group BRIDGESTONE CORPORATION (JP) 2016-08-02 US disclosed
US-8895670-B2 Functionalized polymers and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2014-11-25 US disclosed
EP-2699606-A2 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP Bridgestone Corporation (JP) 2014-02-26 EP disclosed
EP-2483317-B1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2014-02-26 EP disclosed
US-20140018500-A1 Polymers Functionalized With A Carboxylic Or Thiocarboxylic Ester Containing A Silylated Amino Group BRIDGESTONE CORPORATION (JP) 2014-01-16 US disclosed
WO-2012135451-A2 POLYMERS FUNCTIONALIZED WITH A CARBOXYLIC OR THIOCARBOXYLIC ESTER CONTAINING A SILYLATED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2012-10-04 WO disclosed
EP-2483317-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-08-08 EP disclosed
US-20120184677-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2012-07-19 US disclosed
WO-2011041534-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-04-07 WO disclosed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US disclosed