Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 13/20 | 0.53 |
| ▸ | MAOB | P27338 | 12/20 | 0.53 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641 | 0.86 | PRF1 (0.65) | PRF1MAOAMAOBKCNJ1KCNH2 | |
| SCHEMBL29366960 | 0.86 | PRF1 (0.65) | PRF1MAOAMAOBKCNJ1KCNH2 | |
| SCHEMBL10921243 | 0.80 | MAPT (0.50) | PRF1MAOAMAOBKMT2AGAA | |
| Tetrahydrofuran SCHEMBL22089885 | 0.78 | PRF1 (0.56) | PRF1MAOAMAOBKCNJ1KCNH2 | |
| SCHEMBL8798324 | 0.78 | MAPT (0.62) | MAOAMAOBKMT2AGAAMAPT | |
| Benzonitrile SCHEMBL29071525 | 0.77 | MAOA (0.69) | PRF1MAOAMAOBKCNJ1KCNH2 | |
| Toluene SCHEMBL28417431 | 0.77 | PRF1 (0.55) | PRF1MAOAMAOBKCNJ1KCNH2 | |
| SCHEMBL14397627 | 0.76 | KMT2A (0.65) | PRF1MAOAKMT2AGAAMAPT | |
| SCHEMBL6104915 | 0.76 | MAOA (0.50) | MAOAMAOB | |
| SCHEMBL10923806 | 0.75 | MAPT (0.39) | PRF1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9402842-B2 | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2016-08-02 | — | — | US | disclosed |
| US-20160081999-A1 | SYNTHESIS AND USE OF DUAL TYROSYL-DNA PHOSPHODIESTERASE I (Tdp1) - TOPOISOMERASE I (Top1) INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2016-03-24 | — | — | US | disclosed |
| US-9175002-B2 | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2015-11-03 | — | — | US | disclosed |
| US-20150133445-A1 | SYNTHESIS AND USE OF DUAL TYROSYL-DNA PHOSPHODIESTERASE I (Tdp1) - TOPOISOMERASE I (Top1) INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-14 | — | — | US | disclosed |
| US-8912213-B2 | Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2014-12-16 | — | — | US | disclosed |
| EP-2391602-B1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2013-12-04 | — | — | EP | disclosed |
| US-8362065-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
| CN-102325753-A | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2012-01-18 | — | — | CN | disclosed |
| US-8084620-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-27 | — | — | US | disclosed |
| CN-100349569-C | Water-soluble triazole fungicide | SANKYO CO (JP) | 2007-11-21 | — | — | CN | disclosed |
| US-7230023-B2 | Water-soluble triazole fungicide | SANKYO COMPANY, LIMITED (JP) | 2007-06-12 | — | — | US | disclosed |
| CN-1720913-A | Water-soluble triazole fungicide | SANKYO CO (JP) | 2006-01-18 | — | — | CN | disclosed |
| US-20040198790-A1 | Water-soluble triazole fungicide | SANKYO COMPANY, LIMITED (JP) | 2004-10-07 | — | — | US | disclosed |
| CN-1503795-A | Water-soluble triazole antifungal agents | ������������ʽ���� | 2004-06-09 | — | — | CN | disclosed |
| EP-1362856-A1 | WATER-SOLUBLE TRIAZOLE FUNGICIDE | Sankyo Company, Limited (JP) | 2003-11-19 | — | — | EP | disclosed |
| EP-0911320-B1 | 1,2-Di-substituted benzenecarboxamide derivative, hair growth promoter and external composition for skin using the same | SHISEIDO CO LTD (JP) | 2002-07-24 | — | — | EP | disclosed |
| US-6114325-A | 1,2-di-substituted benzene-carboxamide derivative, hair growth promoter and external composition for skin using the same | SHISEIDO CO., LTD. (JP) | 2000-09-05 | — | — | US | disclosed |
| CN-1224712-A | 1,2-Di-substituted benzene-carboxamide derivative, hair growth promoter and external composition for skin using the same | SHISEIDO CO LTD (JP) | 1999-08-04 | — | — | CN | disclosed |
| EP-0911320-A2 | 1,2-Di-substituted benzenecarboxamide derivative, hair growth promoter and external composition for skin using the same | SHISEIDO COMPANY LIMITED (JP) | 1999-04-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150133445-A1 | SYNTHESIS AND USE OF DUAL TYROSYL-DNA PHOSPHODIESTERASE I (Tdp1) - TOPOISOMERASE I (Top1) INHIBITORS | TDP1, TOP1, TDP2 | PRF1 2329/4885MAOA 720/4885MAOB 711/4885 |
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | PRF1 2843/4885MAOA 3150/4885MAOB 2629/4885 |
| US-20160081999-A1 | SYNTHESIS AND USE OF DUAL TYROSYL-DNA PHOSPHODIESTERASE I (Tdp1) - TOPOISOMERASE I (Top1) INHIBITORS | TDP1, TOP1, TDP2 | PRF1 2329/4885MAOA 720/4885MAOB 711/4885 |
| US-20040198790-A1 | Water-soluble triazole fungicide | ERG28, CYP51A1, XDH | PRF1 269/4885MAOA 1236/4885MAOB 1364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.