Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14802408 | 0.94 | MAPT (0.58) | NPC1RAB9ALMNASMN1; SMN2MEN1 | |
| SCHEMBL14802389 | 0.81 | SMN1; SMN2 (0.63) | NPC1RAB9ALMNASMN1; SMN2AHR | |
| SCHEMBL28863360 | 0.79 | ALDH1A1 (0.62) | NPC1RAB9ALMNASMN1; SMN2AHR | |
| SCHEMBL3790093 | 0.79 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL24791968 | 0.77 | HDAC1 (0.60) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8291293 | 0.77 | HDAC2 (0.68) | NPC1RAB9ALMNASMN1; SMN2AHR | |
| SCHEMBL28587110 | 0.77 | ALDH1A1 (0.74) | NPC1RAB9ALMNASMN1; SMN2AHR | |
| SCHEMBL14817822 | 0.77 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL14802407 | 0.75 | MAPT (0.66) | NPC1RAB9ALMNASMN1; SMN2MEN1 | |
| SCHEMBL7244510 | 0.74 | F10 (0.79) | NPC1RAB9ALMNASMN1; SMN2AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9035057-B2 | Dihydroethidine analogues and uses thereof | WASHINGTON UNIVERSITY (US) | 2015-05-19 | — | — | US | disclosed |
| US-20130079522-A1 | DIHYDROETHIDINE ANALOGUES AND USES THEREOF | WASHINGTON UNIVERSITY (US) | 2013-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079522-A1 | DIHYDROETHIDINE ANALOGUES AND USES THEREOF | NOX4, QDPR, ROS1 | NPC1 1122/4885RAB9A 440/4885LMNA 3548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.