Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 3/20 | 0.48 |
| ▸ | WNT3A | P56704 | 13/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912371 | 0.87 | WNT3A (0.45) | WNT3ASMN1; SMN2 | |
| SCHEMBL17243385 | 0.85 | WNT3A (0.55) | WDR5WNT3A | |
| SCHEMBL249965 | 0.85 | WNT3A (0.54) | WDR5WNT3A | |
| SCHEMBL10258532 | 0.85 | PTGES (0.41) | SMN1; SMN2 | |
| SCHEMBL17243386 | 0.83 | WNT3A (0.46) | WDR5WNT3A | |
| SCHEMBL249342 | 0.82 | WNT3A (0.66) | WNT3A | |
| SCHEMBL249160 | 0.81 | WNT3A (0.53) | WDR5WNT3A | |
| SCHEMBL10258040 | 0.81 | WNT3A (0.53) | WDR5WNT3A | |
| SCHEMBL247828 | 0.80 | WNT3A (0.51) | WDR5WNT3A | |
| SCHEMBL248465 | 0.79 | WNT3A (0.53) | WDR5WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181235-B2 | Substituted pyridines for modulating the WNT signaling pathway | NOVARTIS AG (CH) | 2015-11-10 | — | — | US | disclosed |
| US-20130079328-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY | NOVARTIS AG (CH) | 2013-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079328-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY | WNT3A, WNT1, WNT3 | WDR5 580/4885WNT3A 1/4885SMN1; SMN2 4423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.