Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14803886 | 0.85 | POLB (0.50) | ALDH1A1L3MBTL1NPSR1KMT2ASMN1; SMN2 | |
| SCHEMBL14818785 | 0.83 | ALDH1A1 (0.57) | ALDH1A1GAAL3MBTL1NPSR1KMT2A | |
| SCHEMBL14803773 | 0.73 | GAA (0.42) | ALDH1A1GAAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL13748300 | 0.72 | NAMPT (0.47) | GAALMNA | |
| SCHEMBL12341052 | 0.71 | MEN1 (0.42) | ALDH1A1GAAKMT2AMEN1KDM4E | |
| SCHEMBL8049390 | 0.70 | ALDH1A1 (0.77) | ALDH1A1GAAL3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL38664985 | 0.68 | LMNA (0.48) | ALDH1A1GAAL3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL14664146 | 0.68 | ALDH1A1 (0.53) | ALDH1A1GAAL3MBTL1NPSR1KMT2A | |
| SCHEMBL13434151 | 0.68 | ALDH1A1 (0.64) | ALDH1A1GAAL3MBTL1NPSR1KMT2A | |
| SCHEMBL8907510 | 0.68 | ALDH1A1 (0.53) | ALDH1A1GAAL3MBTL1NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169246-B2 | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof | SANOFI (FR) | 2015-10-27 | — | — | US | disclosed |
| US-20140235616-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2014-08-21 | — | — | US | disclosed |
| US-20130079337-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079337-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | CYP11B2, COQ8A, CYP1A2 | ALDH1A1 88/4885GAA 1467/4885L3MBTL1 4514/4885 |
| US-20140235616-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | CYP11B2, CYP1A2, COQ8A | ALDH1A1 97/4885GAA 1631/4885L3MBTL1 4476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.