Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20339238 | 0.73 | CYP11B2 (0.50) | CYP11B2CYP11B1 | |
| SCHEMBL28344812 | 0.69 | CYP11B2 (0.55) | CYP11B2CYP11B1 | |
| SCHEMBL28344944 | 0.69 | CYP11B2 (0.56) | CYP11B2CYP11B1 | |
| SCHEMBL27277040 | 0.67 | PDE4A (0.44) | MAPK14 | |
| SCHEMBL20339309 | 0.66 | CYP11B1 (0.51) | CYP11B2CYP11B1 | |
| SCHEMBL28226097 | 0.66 | ESR1 (0.41) | CYP11B2MAPK14 | |
| SCHEMBL4373862 | 0.64 | ACHE (0.43) | — | |
| SCHEMBL29698205 | 0.64 | ACHE (0.43) | — | |
| SCHEMBL15315959 | 0.64 | LMNA (0.37) | — | |
| SCHEMBL6039495 | 0.63 | CYP1A2 (0.49) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2757882-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013043518-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-03-28 | — | — | WO | disclosed |