Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | UBE2M | P61081 | 1/20 | 0.50 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PKLR | P30613 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14815248 | 0.95 | CACNA1B (0.49) | HSD11B1UBE2MDCUN1D1CACNA1BALDH1A1 | |
| SCHEMBL14815064 | 0.87 | HRH1 (0.45) | CACNA1BALDH1A1PKLRNR1I2HDAC8 | |
| SCHEMBL14815463 | 0.84 | HSD11B1 (0.56) | HSD11B1UBE2MDCUN1D1HPGDPOLB | |
| SCHEMBL14814826 | 0.83 | HSD11B1 (0.58) | HSD11B1UBE2MDCUN1D1CACNA1BHPGD | |
| SCHEMBL14815226 | 0.78 | HSD11B1 (0.56) | HSD11B1UBE2MDCUN1D1ALDH1A1HPGD | |
| SCHEMBL14815148 | 0.78 | DRD2 (0.48) | CACNA1BALDH1A1HPGDSMN1; SMN2HDAC8 | |
| SCHEMBL14815284 | 0.76 | MGLL (0.56) | HSD11B1SMN1; SMN2 | |
| SCHEMBL14815382 | 0.76 | SIGMAR1 (0.46) | CACNA1BALDH1A1 | |
| SCHEMBL14814588 | 0.75 | ALDH1A1 (0.47) | HSD11B1UBE2MDCUN1D1CACNA1BALDH1A1 | |
| SCHEMBL14833243 | 0.75 | ALDH1A1 (0.47) | HSD11B1UBE2MDCUN1D1CACNA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130085142-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | ABBVIE INC. (US) | 2013-04-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085142-A1 | SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS | CACNA1C, CACNA1E, CACNA1D | HSD11B1 2566/4885UBE2M 4772/4885DCUN1D1 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.