Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309082 | 0.92 | KDM5A (0.58) | GABRA1GABRB1GABRA3GABRB2KDM5A | |
| SCHEMBL14830067 | 0.84 | CSF1R (0.54) | KDM5AKDM5BALOX5CSF1R | |
| SCHEMBL18584559 | 0.82 | KDM5A (0.57) | ALOX15KDM5AKDM5BALOX5 | |
| SCHEMBL14830064 | 0.82 | KDM5A (0.52) | ALOX15KDM5AKDM5B | |
| SCHEMBL31298134 | 0.81 | ALDH1A1 (0.59) | KDM5AKDM5BALOX5 | |
| SCHEMBL14829865 | 0.81 | ALDH1A1 (0.59) | KDM5AKDM5BALOX5 | |
| SCHEMBL4647482 | 0.81 | KDM5A (0.64) | KDM5AKDM5B | |
| SCHEMBL5308554 | 0.80 | KDM5A (0.55) | KDM5AKDM5BALOX5 | |
| SCHEMBL14830735 | 0.80 | ALOX15 (0.64) | ALOX15CSF1R | |
| SCHEMBL14829933 | 0.78 | KDM5A (0.48) | ALOX15KDM5AKDM5BALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760840-A1 | QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | Bristol-Myers Squibb Company (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013048942-A1 | QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |