Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14830064 | 0.85 | KDM5A (0.52) | KDM5AKDM5BALDH1A1GAAHPGD | |
| SCHEMBL14830735 | 0.82 | ALOX15 (0.64) | ALOX15 | |
| SCHEMBL14830067 | 0.80 | CSF1R (0.54) | KDM5AKDM5BALDH1A1GAAHPGD | |
| SCHEMBL14829946 | 0.80 | KDM5A (0.47) | KDM5AKDM5BALDH1A1GAAKDM4E | |
| SCHEMBL31298134 | 0.79 | ALDH1A1 (0.59) | KDM5AKDM5BALDH1A1GAAHPGD | |
| SCHEMBL14829865 | 0.79 | ALDH1A1 (0.59) | KDM5AKDM5BALDH1A1GAAHPGD | |
| SCHEMBL14829907 | 0.78 | GABRA1 (0.53) | KDM5AKDM5BALOX15ALOX5 | |
| SCHEMBL9452225 | 0.78 | ALDH1A1 (0.48) | ALDH1A1GAAHPGDKDM4EMEN1 | |
| SCHEMBL14830757 | 0.77 | GAA (0.58) | KDM5AKDM5BALDH1A1GAAHPGD | |
| SCHEMBL3640988 | 0.76 | KIF11 (0.50) | ALDH1A1GAAHPGDKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760840-A1 | QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | Bristol-Myers Squibb Company (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013048942-A1 | QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-04 | — | — | WO | disclosed |