Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP3 | P15309 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450353 | 0.92 | ACP3 (0.53) | ACP3MEN1KMT2ACACNA1GCACNA2D1 | |
| SCHEMBL10775144 | 0.92 | ACP3 (0.52) | ACP3MEN1KMT2ACACNA1GCACNA2D1 | |
| SCHEMBL4058257 | 0.88 | IDO1 (0.50) | MEN1KMT2ACNR1CACNA1GCACNA2D1 | |
| SCHEMBL1979065 | 0.85 | TSHR (0.44) | MEN1KMT2ACNR1LMNAIDO1 | |
| SCHEMBL11552637 | 0.79 | HTR2A (0.44) | ACP3LMNA | |
| SCHEMBL17398566 | 0.78 | ACP3 (0.41) | ACP3MEN1KMT2ALMNAIDO1 | |
| SCHEMBL5556253 | 0.76 | LMNA (0.42) | ACP3CACNA1GLMNAP2RX7ADRB2 | |
| SCHEMBL5555304 | 0.76 | AOC3 (0.60) | SLC6A2SLC6A4 | |
| SCHEMBL6002784 | 0.76 | ACP3 (0.44) | ACP3MEN1KMT2ALMNAIDO1 | |
| SCHEMBL8324166 | 0.74 | ACP3 (0.47) | ACP3MEN1KMT2ACACNA1GCACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760845-A1 | HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013049250-A1 | HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2013-04-04 | — | — | WO | disclosed |