⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1483373 | 0.99 | — | — | |
| Bromide SCHEMBL4264424 | 0.79 | ALOX5AP (0.36) | — | |
| SCHEMBL5215973 | 0.79 | KDR (0.31) | — | |
| SCHEMBL1482889 | 0.78 | ALOX5AP (0.38) | — | |
| SCHEMBL5218539 | 0.77 | CYP11B1 (0.36) | — | |
| SCHEMBL5220760 | 0.76 | CYP11B1 (0.36) | — | |
| Bromide SCHEMBL4464997 | 0.75 | PTPN11 (0.31) | — | |
| SCHEMBL4475930 | 0.75 | HRH4 (0.37) | — | |
| Bromide SCHEMBL4460963 | 0.75 | CHRNB2 (0.31) | — | |
| SCHEMBL5219926 | 0.72 | CNR2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541440-B2 | Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics | SANOFI (FR) | 2013-09-24 | — | — | US | claimed |
| US-20110077264-A1 | DERIVATIVES OF 5-PYRIDINYL-1-AZABICYCLO[3.2.1]OCTANE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2011-03-31 | — | — | US | claimed |
| EP-1915375-B1 | DERIVATIVES OF 5-PYRIDINYL-1-AZABICYCLO[3.2.1]OCTANE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2009-10-07 | — | — | EP | claimed |
| US-20080146608-A1 | DERIVATIVES OF 5-PYRIDINYL-1-AZABICYCLO[3.2.1]OCTANE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2008-06-19 | — | — | US | claimed |
| US-8541440-B2 | Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics | SANOFI (FR) | 2013-09-24 | — | — | US | disclosed |
| US-20110077264-A1 | DERIVATIVES OF 5-PYRIDINYL-1-AZABICYCLO[3.2.1]OCTANE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2011-03-31 | — | — | US | disclosed |
| US-7863290-B2 | Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2011-01-04 | — | — | US | disclosed |
| EP-1915375-B1 | DERIVATIVES OF 5-PYRIDINYL-1-AZABICYCLO[3.2.1]OCTANE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2009-10-07 | — | — | EP | disclosed |
| US-20080146608-A1 | DERIVATIVES OF 5-PYRIDINYL-1-AZABICYCLO[3.2.1]OCTANE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2008-06-19 | — | — | US | disclosed |