Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 9/20 | 0.77 |
| ▸ | PARP1 | P09874 | 5/20 | 0.77 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.77 |
| ▸ | NPC1 | O15118 | 3/20 | 0.77 |
| ▸ | RAB9A | P51151 | 3/20 | 0.77 |
| ▸ | BCHE | P06276 | 1/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | ACHE | P22303 | 1/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.77 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | GABRP | O00591 | 3/20 | 0.70 |
| ▸ | GABRD | O14764 | 3/20 | 0.70 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.70 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.70 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.70 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311580 | 0.87 | TNKS (1.00) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| SCHEMBL29677954 | 0.87 | TNKS (1.00) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| SCHEMBL29384142 | 0.87 | TNKS (1.00) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| SCHEMBL127446 | 0.87 | TNKS (1.00) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| SCHEMBL29773081 | 0.87 | TNKS (1.00) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| Flavone SCHEMBL27534477 | 0.85 | TNKS (0.85) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| SCHEMBL1883775 | 0.85 | FTO (1.00) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| SCHEMBL30000045 | 0.85 | FTO (1.00) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| SCHEMBL12829685 | 0.83 | CYP3A4 (0.79) | TNKSPARP1TNKS2SMN1; SMN2KDM4E | |
| SCHEMBL311820 | 0.83 | FTO (0.78) | TNKSPARP1TNKS2SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057137-B1 | S-(+)-7-[3-N-SUBSTITUTED AMINO-2-HYDROXYPROPOXY]FLAVONES | COUNCIL SCIENT IND RES (IN) | 2013-10-23 | — | — | EP | disclosed |
| US-20110077294-A1 | R-(-) / S-(+)-7-[3-N SUBSTITUTED AMINO-2 HYDROXYPROPOXY] FLAVONES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077294-A1 | R-(-) / S-(+)-7-[3-N SUBSTITUTED AMINO-2 HYDROXYPROPOXY] FLAVONES | HTR7, PNMT, PRMT7 | TNKS 3422/4885PARP1 2675/4885TNKS2 3523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.