SCHEMBL127446

SCHEMBL127446

O=c1cc(-c2ccc(O)cc2)oc2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNKS O95271 9/20 1.00
SMN1; SMN2 Q16637 5/20 1.00
NPC1 O15118 5/20 1.00
RAB9A P51151 5/20 1.00
KDM4E B2RXH2 4/20 1.00
TDP1 Q9NUW8 2/20 1.00
BCHE P06276 1/20 1.00
POLB P06746 1/20 1.00
ACHE P22303 1/20 1.00
PLA2G2A P14555 3/20 0.81
PLA2G4A P47712 3/20 0.81
PARP1 P09874 5/20 0.75
TNKS2 Q9H2K2 5/20 0.75
CYP3A4 P08684 5/20 0.75
HPGD P15428 5/20 0.75
CYP19A1 P11511 3/20 0.75
TP53 P04637 2/20 0.75
GABRP O00591 2/20 0.75
GABRD O14764 2/20 0.75
GABRA1 P14867 2/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29773081 1.00 TNKS (1.00) TNKSSMN1; SMN2NPC1RAB9AKDM4E
Flavone SCHEMBL27534477 0.92 TNKS (0.85) TNKSSMN1; SMN2NPC1RAB9AKDM4E
Flavone SCHEMBL3515129 0.91 CYP19A1 (0.86) TNKSSMN1; SMN2NPC1RAB9AKDM4E
SCHEMBL30718966 0.90 TNKS (0.81) TNKSSMN1; SMN2NPC1RAB9AKDM4E
SCHEMBL1483977 0.87 TNKS (0.77) TNKSSMN1; SMN2NPC1RAB9AKDM4E
Flavone SCHEMBL14246840 0.87 MAOB (0.78) TNKSSMN1; SMN2NPC1RAB9AKDM4E
SCHEMBL23070093 0.86 TNKS (0.93) TNKSSMN1; SMN2NPC1RAB9AKDM4E
Flavone SCHEMBL18879 0.86 TNKS (1.00) TNKSSMN1; SMN2NPC1RAB9AKDM4E
Flavone SCHEMBL31316377 0.86 TNKS (1.00) TNKSSMN1; SMN2NPC1RAB9AKDM4E
Flavone SCHEMBL15676601 0.86 TNKS (1.00) TNKSSMN1; SMN2NPC1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 739 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023150072-A1 COMPOSITIONS AND METHODS FOR THE PRESERVATION OF PLANT MATTER SINCLAIR DAVID A (US) 2023-08-10 WO claimed
US-20230119060-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING, AS ACTIVE INGREDIENT, COMPLEX OF BIGUANIDE-BASED COMPOUND AND FLAVONE, HYDROXYFLAVONE, FLAVANONE, FLAVONE DERIVATIVE, HYDROXYFLAVONE DERIVATIVE, OR FLAVANONE DERIVATIVE MEDIENCE CO., LTD. (KR) 2023-04-20 US claimed
CN-107308923-B Preparation method of high performance liquid chromatography stationary phase and chromatographic column SOUTHWEST UNIVERSITY (CN) 2019-12-10 CN claimed
US-20160367497-A1 METHODS AND COMPOSITIONS FOR TREATING NEUROPATHIES WASHINGTON UNIVERSITY 2016-12-22 US claimed
EP-2934431-A1 COMPOSITIONS AND/OR ARTICLES WITH IMPROVED SOLUBILITY OF A SOLID ACTIVE The Procter & Gamble Company (US) 2015-10-28 EP claimed
EP-1856085-B1 FLAVONOID COMPOUNDS AND USES THEREOF HOWARD FLOREY INST PTY LTD (AU) 2015-07-08 EP claimed
EP-2875359-A2 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLIC SYNDROME DISORDERS Charles R Drew University of Medicine and Science (US) 2015-05-27 EP claimed
WO-2014100067-A1 COMPOSITIONS AND/OR ARTICLES WITH IMPROVED SOLUBILITY OF A SOLID ACTIVE THE PROCTER & GAMBLE COMPANY (US) 2014-06-26 WO claimed
US-20140178314-A1 COMPOSITIONS AND/OR ARTICLES WITH IMPROVED SOLUBILITY OF A SOLID ACTIVE THE PROCTER & GAMBLE COMPANY (US) 2014-06-26 US claimed
EP-2729113-A2 PERSONAL CARE COMPOSITIONS WITH IMPROVED SOLUBILITY OF A SOLID COSMETIC ACTIVE SUBSTANCE The Procter and Gamble Company (US) 2014-05-14 EP claimed
US-20060205767-A1 Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases HEPALINK (HONG KONG) LIMITED (HK) 2006-09-14 US claimed
WO-2006045096-A2 FLAVANOIDS AND ISOFLAVANOIDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES RESVERLOGIX CORP. (CA) 2006-04-27 WO claimed
US-20060002914-A1 treating or preventing axonal degradation in neuropathic diseases in mammals; axonopathy; administering an agent (such as NAD, NADH) that increases sirtuin activity in diseased and/or injured neurons and supporting cells in an amount effective to decrease axonal degeneration NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2006-01-05 US claimed
WO-2006001982-A2 METHODS AND COMPOSITIONS FOR TREATING NEUROPATHIES WASHINGTON UNIVERSITY (US) 2006-01-05 WO claimed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
WO-2005020881-A2 COMPOSITIONS OF FLAVONOIDS AND FLAVONOID-CONTAINING EXTRACTS AND THE TREATMENT OF DISEASES SHANGHAI COMMAN PHARMACEUTICAL CO. (US) 2005-03-10 WO claimed
JP-2003504327-A 2003-02-04 JP claimed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 EP claimed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO claimed
WO-1996031206-A2 FLAVONES AND COUMARINS AS AGENTS FOR THE TREATMENT OF ATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 1996-10-10 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060205767-A1 Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases APOB, APOL1, FABP3 TNKS 4486/4885SMN1; SMN2 2736/4885NPC1 26/4885
US-20140178314-A1 COMPOSITIONS AND/OR ARTICLES WITH IMPROVED SOLUBILITY OF A SOLID ACTIVE ASS1, F12, CUTA TNKS 4150/4885SMN1; SMN2 2456/4885NPC1 1398/4885
US-20230119060-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING, AS ACTIVE INGREDIENT, COMPLEX OF BIGUANIDE-BASED COMPOUND AND FLAVONE, HYDROXYFLAVONE, FLAVANONE, FLAVONE DERIVATIVE, HYDROXYFLAVONE DERIVATIVE, OR FLAVANONE DERIVATIVE SLC5A2, SLC5A1, SLC5A6 TNKS 4575/4885SMN1; SMN2 3592/4885NPC1 1550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.