Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14844536 | 0.80 | CHRNB2 (0.32) | CHRNB2CHRNA4 | |
| SCHEMBL14845191 | 0.70 | RAB9A (0.37) | KMT2A | |
| SCHEMBL1190290 | 0.69 | OTUD7B (0.36) | CHRNB2CHRNA4NISCHLTA4H | |
| SCHEMBL31343493 | 0.68 | CYP2A6 (0.35) | NISCHLTA4H | |
| SCHEMBL16652167 | 0.68 | LTA4H (0.36) | NISCHLTA4HSLC6A2SLC6A4 | |
| SCHEMBL19859215 | 0.67 | HPGD (0.37) | LTA4HP2RX7 | |
| SCHEMBL19859207 | 0.67 | CYSLTR1 (0.38) | LTA4HP2RX7KMT2A | |
| SCHEMBL16685041 | 0.64 | CHRNB2 (0.40) | CHRNB2CHRNA4JAK2HTR1ASLC6A2 | |
| SCHEMBL31477187 | 0.63 | GRIN2D (0.32) | NISCH | |
| SCHEMBL17633645 | 0.62 | KMT2A (0.40) | CHRNB2CHRNA4HTR1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013050341-A1 | AZABENZOXAZINE DERIVATIVES AS CRAC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-11 | — | — | WO | disclosed |