Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | DCK | P27707 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14841785 | 0.76 | KDM4E (0.35) | KDM4EGFERMAPTALDH1A1POLB | |
| SCHEMBL14844465 | 0.76 | CYP2E1 (0.37) | CYP3A4CYP2C19CYP11B2CYP11B1 | |
| SCHEMBL14845191 | 0.75 | RAB9A (0.37) | KDM4EGFERMAPTALDH1A1CYP1A2 | |
| SCHEMBL15020526 | 0.74 | ORAI1 (0.41) | KDM4EGFERMAPTALDH1A1POLB | |
| SCHEMBL14840855 | 0.73 | KDM4E (0.38) | KDM4EGFERMAPTALDH1A1POLB | |
| SCHEMBL1459744 | 0.69 | KDM4E (0.42) | KDM4EGFERMAPTALDH1A1POLB | |
| SCHEMBL14844199 | 0.69 | CHRNB2 (0.36) | MEN1KMT2A | |
| SCHEMBL14844390 | 0.68 | STIM1 (0.36) | — | |
| SCHEMBL1458937 | 0.66 | MAPT (0.39) | KDM4EGFERMAPTALDH1A1POLB | |
| SCHEMBL14840467 | 0.64 | CYP1A1 (0.34) | MAPTALDH1A1CYP1A2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013050341-A1 | AZABENZOXAZINE DERIVATIVES AS CRAC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-11 | — | — | WO | claimed |
| WO-2013050341-A1 | AZABENZOXAZINE DERIVATIVES AS CRAC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-11 | — | — | WO | disclosed |