SCHEMBL14848622

SCHEMBL14848622

Cc1ccc2c(c1)c1cc(-c3ccc(N(c4ccccc4)c4ccc5ccc6c(N(c7ccccc7)c7ccc(-c8ccc9c(c8)c8cc(C)ccc8n9-c8ccccc8)cc7)ccc7ccc4c5c76)cc3)ccc1n2-c1ccccc1

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NLRP3 Q96P20 1/20 0.32
▸ SIRT2 Q8IXJ6 2/20 0.32
▸ SIRT1 Q96EB6 2/20 0.32
▸ PTGER4 P35408 1/20 0.32
▸ GAA P10253 1/20 0.31
▸ GFER P55789 1/20 0.31
▸ RXFP1 Q9HBX9 2/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ TSPO P30536 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ HTT P42858 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ ATM Q13315 1/20 0.31
▸ L3MBTL1 Q9Y468 1/20 0.31
▸ PDE10A Q9Y233 1/20 0.31
▸ KMT2A Q03164 3/20 0.30
▸ MEN1 O00255 2/20 0.30
▸ NR1I2 O75469 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14848556 0.93 KDM4E (0.38) SIRT2SIRT1PTGER4GAARXFP1
SCHEMBL14848625 0.92 GAA (0.33) NLRP3GAAGFERALDH1A1LMNA
SCHEMBL14848553 0.90 KDM4E (0.42) PTGER4ALDH1A1TSPOKDM4EATM
SCHEMBL20349159 0.88 KDM4E (0.40) PTGER4ALDH1A1TSPOKDM4EATM
SCHEMBL17117425 0.87 KDM4E (0.35) SIRT2SIRT1PTGER4GAARXFP1
SCHEMBL15306438 0.86 KDM4E (0.39) SIRT2SIRT1PTGER4GAAGFER
SCHEMBL16001347 0.85 PDE10A (0.32) NLRP3GAAGFERLMNAHPGD
SCHEMBL12362697 0.85 PDK2 (0.30) PDE10A
SCHEMBL7254005 0.84 HPGD (0.33) SIRT2SIRT1GAAGFERALDH1A1
SCHEMBL14848627 0.83 L3MBTL1 (0.40) PTGER4RXFP1ALDH1A1TSPOHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11158812-B2 Light-emitting element, light-emitting device, electronic device, lighting device, and pyrene-based compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2021-10-26 — — US disclosed
US-20190273207-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Pyrene-Based Compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2019-09-05 — — US disclosed
US-10230052-B2 Light-emitting element, light-emitting device, electronic device, lighting device, and pyrene-based compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2019-03-12 — — US disclosed
US-9911923-B2 Light-emitting element, light-emitting device, electronic device, lighting device, and pyrene-based compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2018-03-06 — — US disclosed
US-9911923-B2 Light-emitting element, light-emitting device, electronic device, lighting device, and pyrene-based compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2018-03-06 — — US disclosed
US-20160254451-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Pyrene-Based Compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-01 — — US disclosed
US-9343681-B2 Light-emitting element, light-emitting device, electronic device, lighting device, and pyrene-based compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-05-17 — — US disclosed
US-20130087773-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Pyrene-Based Compound SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-04-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130087773-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Pyrene-Based Compound PPOX, PNPO, ESR1 NLRP3 91/4885SIRT2 4215/4885SIRT1 3944/4885
US-20190273207-A1 Light-Emitting Element, Light-Emitting Device, Electronic Device, Lighting Device, and Pyrene-Based Compound PPOX, PNPO, ESR1 NLRP3 91/4885SIRT2 4215/4885SIRT1 3944/4885
US-10230052-B2 Light-emitting element, light-emitting device, electronic device, lighting device, and pyrene-based compound PPOX, PNPO, ESR1 NLRP3 91/4885SIRT2 4215/4885SIRT1 3944/4885
US-11158812-B2 Light-emitting element, light-emitting device, electronic device, lighting device, and pyrene-based compound PPOX, PNPO, ESR1 NLRP3 91/4885SIRT2 4215/4885SIRT1 3944/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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