Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.32 |
| ▸ | FAAH | O00519 | 3/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.31 |
| ▸ | AURKA | O14965 | 2/20 | 0.30 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856796 | 0.91 | TRPA1 (0.33) | P2RX7BACE1CNR2TRPA1FAAH | |
| SCHEMBL14856435 | 0.89 | OGA (0.33) | P2RX7CNR2TRPA1FAAHRORC | |
| SCHEMBL186462 | 0.88 | BACE1 (0.32) | P2RX7BACE1CNR2TRPA1FAAH | |
| SCHEMBL2809241 | 0.88 | CNR2 (0.35) | P2RX7BACE1CNR2TRPA1HDAC3 | |
| SCHEMBL14856710 | 0.86 | FAAH (0.35) | P2RX7CNR2TRPA1FAAHHDAC3 | |
| SCHEMBL14856698 | 0.86 | P2RX7 (0.32) | P2RX7CNR2TRPA1FAAH | |
| SCHEMBL14856421 | 0.86 | FAAH (0.33) | P2RX7BACE1CNR2TRPA1FAAH | |
| SCHEMBL14856622 | 0.86 | P2RX7 (0.32) | P2RX7CNR2TRPA1FAAHAURKA | |
| SCHEMBL2812751 | 0.85 | P2RX7 (0.37) | P2RX7CNR2TRPA1HDAC3HDAC1 | |
| SCHEMBL14856774 | 0.84 | FAAH (0.34) | P2RX7TRPA1FAAHTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |