Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806201 | 0.88 | NPC1 (0.36) | BACE1TRPA1NTRK1P2RX7CNR2 | |
| SCHEMBL14856424 | 0.88 | P2RX7 (0.33) | BACE1TRPA1P2RX7TRPV1FAAH | |
| SCHEMBL14856796 | 0.86 | TRPA1 (0.33) | BACE1TRPA1NTRK1P2RX7TRPV1 | |
| SCHEMBL14856698 | 0.84 | P2RX7 (0.32) | TRPA1P2RX7FAAHBDKRB1CNR2 | |
| SCHEMBL14856435 | 0.83 | OGA (0.33) | TRPA1P2RX7TRPV1FAAHCNR2 | |
| SCHEMBL2812751 | 0.83 | P2RX7 (0.37) | TRPA1NTRK1P2RX7CNR2 | |
| SCHEMBL14856710 | 0.83 | FAAH (0.35) | TRPA1P2RX7TRPV1FAAHCNR2 | |
| SCHEMBL2809241 | 0.82 | CNR2 (0.35) | BACE1TRPA1P2RX7BDKRB1CNR2 | |
| SCHEMBL14856622 | 0.82 | P2RX7 (0.32) | TRPA1P2RX7FAAHCNR2 | |
| SCHEMBL14856421 | 0.82 | FAAH (0.33) | BACE1TRPA1P2RX7TRPV1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |