Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14857328 | 0.84 | KDM4E (0.41) | POLBSMN1; SMN2ALDH1A1TP53KDM4E | |
| SCHEMBL14857330 | 0.84 | THRB (0.48) | SMN1; SMN2LMNAALDH1A1KDM4EGAA | |
| SCHEMBL14857326 | 0.84 | THRB (0.48) | POLBSMN1; SMN2LMNANPC1ALDH1A1 | |
| SCHEMBL14857112 | 0.79 | L3MBTL1 (0.45) | ALDH1A1 | |
| SCHEMBL14857296 | 0.76 | PPARG (0.39) | LMNANPC1ALDH1A1TP53RAB9A | |
| SCHEMBL14857331 | 0.74 | TSHR (0.36) | LMNAALDH1A1TP53 | |
| SCHEMBL14857301 | 0.74 | TSHR (0.36) | LMNAALDH1A1 | |
| SCHEMBL14857312 | 0.74 | KMT2A (0.40) | POLBLMNAALDH1A1GAATHRB | |
| SCHEMBL14857335 | 0.73 | ALDH1A1 (0.36) | POLBSMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL19818799 | 0.71 | L3MBTL1 (0.64) | POLBSMN1; SMN2LMNANPC1FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451796-B1 | TOFA ANALOGS USEFUL IN TREATING DERMATOLOGICAL DISORDERS OR CONDITIONS | DERMIRA CANADA INC (US) | 2013-04-17 | — | — | EP | claimed |