Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14857301 | 0.88 | TSHR (0.36) | TSHRALDH1A1LMNAPPARGNAAA | |
| SCHEMBL14857296 | 0.82 | PPARG (0.39) | TSHRALDH1A1LMNATP53PPARG | |
| SCHEMBL14857335 | 0.77 | ALDH1A1 (0.36) | ALDH1A1PPARGNAAA | |
| SCHEMBL14857312 | 0.76 | KMT2A (0.40) | TSHRALDH1A1LMNAMAPK1 | |
| SCHEMBL14857326 | 0.75 | THRB (0.48) | ALDH1A1LMNAMAPK1 | |
| SCHEMBL14857330 | 0.75 | THRB (0.48) | TSHRALDH1A1LMNAMAPK1 | |
| SCHEMBL14857332 | 0.74 | RAB9A (0.45) | ALDH1A1MAPK1 | |
| SCHEMBL14857112 | 0.73 | L3MBTL1 (0.45) | ALDH1A1 | |
| SCHEMBL28061817 | 0.69 | NAAA (0.50) | TSHRALDH1A1LMNANAAARAD52 | |
| SCHEMBL9358040 | 0.67 | TSHR (0.52) | TSHRALDH1A1LMNATP53NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451796-B1 | TOFA ANALOGS USEFUL IN TREATING DERMATOLOGICAL DISORDERS OR CONDITIONS | DERMIRA CANADA INC (US) | 2013-04-17 | — | — | EP | claimed |