Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14865005 | 0.85 | ALOX5 (0.56) | ALOX5SIRT1KDM4EALDH1A1HPGD | |
| SCHEMBL5234954 | 0.79 | NR4A2 (0.63) | ALOX5NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL28025008 | 0.75 | ALOX5 (0.56) | ALOX5NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL3253095 | 0.73 | KDM4E (0.56) | ALOX5NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL16401274 | 0.73 | NR4A2 (0.55) | ALOX5NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL6313673 | 0.73 | GSK3B (0.56) | ALOX5NR4A2KDM4EALDH1A1MEN1 | |
| SCHEMBL31312633 | 0.73 | ALOX5 (0.57) | ALOX5NR4A2 | |
| SCHEMBL28024554 | 0.73 | ALOX5 (0.54) | ALOX5NR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL9094140 | 0.72 | GAA (0.58) | ALOX5KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL7358358 | 0.72 | SIRT1 (0.49) | ALOX5SIRT1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2581451-A1 | Compounds for inhibiting mammalian s-nitrosoglutathione reductase | Indiana University Research and Technology Corporation (US) | 2013-04-17 | — | — | EP | disclosed |