Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14865010 | 0.85 | ALOX5 (0.55) | ALOX5SIRT1ALDH1A1HPGDKDM4E | |
| SCHEMBL28819192 | 0.84 | SIRT1 (0.69) | ALOX5SIRT1CSF1RALDH1A1CYP1A2 | |
| SCHEMBL5234954 | 0.78 | NR4A2 (0.63) | ALOX5ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL8296306 | 0.76 | PRSS1 (0.55) | SIRT1CSF1RALDH1A1CYP1A2HPGD | |
| SCHEMBL8795558 | 0.75 | ALOX15 (0.68) | ALOX5CSF1RALDH1A1CYP1A2HPGD | |
| SCHEMBL1504534 | 0.73 | ALDH1A1 (0.68) | ALOX5CSF1RALDH1A1CYP1A2HPGD | |
| SCHEMBL16610191 | 0.73 | ALOX15 (0.81) | ALOX5CSF1RALDH1A1CYP1A2HPGD | |
| Methane SCHEMBL28638234 | 0.72 | ALOX15 (0.50) | ALDH1A1CYP1A2HPGDXBP1CYP2C19 | |
| SCHEMBL5506447 | 0.72 | ALOX5 (0.53) | ALOX5ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL16401274 | 0.72 | NR4A2 (0.55) | ALOX5ALDH1A1CYP1A2HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2581451-A1 | Compounds for inhibiting mammalian s-nitrosoglutathione reductase | Indiana University Research and Technology Corporation (US) | 2013-04-17 | — | — | EP | disclosed |