Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PDE5A | O76074 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12324398 | 0.84 | EGFR (0.57) | MAPTNPSR1BLML3MBTL1MEN1 | |
| SCHEMBL14867303 | 0.78 | ALDH1A1 (0.47) | SMN1; SMN2MAPTNPSR1HPGDL3MBTL1 | |
| SCHEMBL14867273 | 0.74 | MAPT (0.44) | SMN1; SMN2MAPTNPSR1TDP1MEN1 | |
| SCHEMBL14867290 | 0.74 | L3MBTL1 (0.41) | SMN1; SMN2MAPTNPSR1L3MBTL1MEN1 | |
| SCHEMBL14867274 | 0.72 | HPRT1 (0.39) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL13407309 | 0.70 | MAPT (0.59) | SMN1; SMN2MAPTNPSR1HPGDBLM | |
| SCHEMBL28469366 | 0.70 | MAPT (0.52) | SMN1; SMN2MAPTNPSR1BLMTDP1 | |
| SCHEMBL14867304 | 0.69 | S1PR4 (0.35) | SMN1; SMN2MAPTNPSR1MEN1KMT2A | |
| SCHEMBL14867280 | 0.69 | CASR (0.37) | MAPTL3MBTL1MEN1KMT2ALMNA | |
| SCHEMBL15743967 | 0.67 | MAPT (0.56) | SMN1; SMN2MAPTNPSR1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883763-B2 | Use of isoquinolones for preparing drugs, novel isoquinolones and method for synthesising same | UNIVERSITE JOSEPH FOURIER (FR) | 2014-11-11 | — | — | US | disclosed |
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2013-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096083-A1 | USE OF ISOQUINOLONES FOR PREPARING DRUGS, NOVEL ISOQUINOLONES AND METHOD FOR SYNTHESISING SAME | GNAQ, HCCS, SDHA | SMN1; SMN2 4740/4885MAPT 4086/4885NPSR1 3494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.