Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | APP | P05067 | 9/20 | 0.59 |
| ▸ | TOP2A | P11388 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | BACE1 | P56817 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | PTGES | O14684 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14875129 | 0.84 | PTGS2 (0.70) | APPTOP2AMAPTBACE1CYP2D6 | |
| SCHEMBL14875128 | 0.84 | PTGS2 (0.70) | APPTOP2AMAPTBACE1CYP2D6 | |
| SCHEMBL2612584 | 0.83 | L3MBTL1 (0.53) | L3MBTL1APPTSHRPTGS2KDM4E | |
| SCHEMBL16199454 | 0.79 | PTGS2 (0.56) | L3MBTL1APPMAPTTSHRHSD17B10 | |
| SCHEMBL2608352 | 0.76 | CA12 (0.50) | L3MBTL1APPMAPTCYP2D6TSHR | |
| SCHEMBL16868833 | 0.76 | PTPN1 (0.71) | APPTOP2AMAPTBACE1CYP2D6 | |
| SCHEMBL14887101 | 0.76 | PTPN1 (0.71) | APPTOP2AMAPTBACE1CYP2D6 | |
| SCHEMBL3454263 | 0.76 | CA12 (0.75) | L3MBTL1CYP2D6TSHRPTGS2CYP2C19 | |
| SCHEMBL2608353 | 0.76 | L3MBTL1 (0.46) | L3MBTL1APPTSHRPTGS2KDM4E | |
| SCHEMBL16229673 | 0.75 | L3MBTL1 (0.47) | L3MBTL1APPMAPTTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130102498-A1 | COMPOSITIONS AND METHODS FOR DETECTING AMYLOID-BETA-DEGRADING ENZYME ACTIVITY | ACADEMIA SINICA (TW) | 2013-04-25 | — | — | US | disclosed |