Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 11/20 | 0.42 |
| ▸ | MMP1 | P03956 | 10/20 | 0.42 |
| ▸ | MMP3 | P08254 | 9/20 | 0.42 |
| ▸ | MMP13 | P45452 | 9/20 | 0.42 |
| ▸ | MMP7 | P09237 | 8/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14878456 | 0.93 | MMP1 (0.43) | MMP9MMP1MMP3MMP13MMP7 | |
| SCHEMBL12905331 | 0.92 | MMP9 (0.41) | MMP9MMP1MMP3MMP13MMP7 | |
| SCHEMBL12942841 | 0.92 | MMP9 (0.44) | MMP9MMP1MMP3MMP13MMP7 | |
| SCHEMBL14878484 | 0.92 | MMP3 (0.44) | MMP9MMP1MMP3MMP13MMP7 | |
| SCHEMBL12905327 | 0.91 | MMP9 (0.41) | MMP9MMP1MMP3MMP13MMP7 | |
| SCHEMBL14878464 | 0.90 | MMP9 (0.43) | MMP9MMP1MMP3MMP13MMP7 | |
| SCHEMBL328472 | 0.90 | MMP1 (0.54) | MMP9MMP1MMP3MMP13MMP7 | |
| SCHEMBL918708 | 0.90 | MMP1 (0.54) | MMP9MMP1MMP3MMP13MMP7 | |
| SCHEMBL919124 | 0.90 | MMP1 (0.53) | MMP9MMP1MMP3MMP13MMP7 | |
| SCHEMBL919122 | 0.90 | MMP1 (0.53) | MMP9MMP1MMP3MMP13MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014028334-A1 | SELECTIVE MMP INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2014-02-20 | — | — | WO | disclosed |
| US-8426415-B2 | Human ADAM-10 inhibitors | SYMPHONY EVOLUTION, INC. (US) | 2013-04-23 | — | — | US | disclosed |