Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 8/20 | 0.41 |
| ▸ | MMP13 | P45452 | 8/20 | 0.41 |
| ▸ | MMP1 | P03956 | 8/20 | 0.41 |
| ▸ | MMP3 | P08254 | 8/20 | 0.41 |
| ▸ | MMP7 | P09237 | 6/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | MMP8 | P22894 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12905351 | 0.92 | MMP1 (0.40) | MMP9MMP13MMP1MMP3MMP7 | |
| SCHEMBL14878466 | 0.91 | MMP1 (0.44) | MMP9MMP13MMP1MMP3MMP7 | |
| SCHEMBL767275 | 0.91 | MMP1 (0.53) | MMP9MMP13MMP1MMP3MMP7 | |
| SCHEMBL14878464 | 0.90 | MMP9 (0.43) | MMP9MMP13MMP1MMP3MMP7 | |
| SCHEMBL12905352 | 0.83 | MMP1 (0.43) | MMP9MMP13MMP1MMP3MMP7 | |
| SCHEMBL12905350 | 0.82 | MMP9 (0.42) | MMP9MMP13MMP1MMP3MMP7 | |
| SCHEMBL14878454 | 0.82 | MMP3 (0.48) | MMP9MMP13MMP1MMP3MMP7 | |
| SCHEMBL778778 | 0.82 | MMP1 (0.56) | MMP9MMP13MMP1MMP3MMP7 | |
| SCHEMBL328467 | 0.82 | MMP1 (0.50) | MMP9MMP13MMP1MMP3MMP7 | |
| SCHEMBL14878456 | 0.81 | MMP1 (0.43) | MMP9MMP13MMP1MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511488-B1 | HUMAN ADAM-10 INHIBITORS | SYMPHONY EVOLUTION INC (US) | 2013-05-22 | — | — | EP | disclosed |
| US-8426415-B2 | Human ADAM-10 inhibitors | SYMPHONY EVOLUTION, INC. (US) | 2013-04-23 | — | — | US | disclosed |
| EP-2436676-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-04-04 | — | — | EP | disclosed |