Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.50 |
| ▸ | MMP9 | P14780 | 12/20 | 0.50 |
| ▸ | MMP3 | P08254 | 12/20 | 0.50 |
| ▸ | MMP13 | P45452 | 10/20 | 0.50 |
| ▸ | MMP7 | P09237 | 10/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 3/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12905346 | 0.91 | MMP1 (0.49) | MMP1MMP9MMP3MMP13MMP7 | |
| SCHEMBL14878466 | 0.90 | MMP1 (0.44) | MMP1MMP9MMP3MMP13MMP7 | |
| SCHEMBL14878456 | 0.90 | MMP1 (0.43) | MMP1MMP9MMP3MMP13MMP7 | |
| SCHEMBL14878482 | 0.90 | MMP1 (0.43) | MMP1MMP9MMP3MMP13MMP7 | |
| SCHEMBL778957 | 0.89 | MMP1 (0.64) | MMP1MMP9MMP3MMP13MMP7 | |
| SCHEMBL14878464 | 0.84 | MMP9 (0.43) | MMP1MMP9MMP3MMP13MMP7 | |
| SCHEMBL14878435 | 0.83 | MMP9 (0.42) | MMP1MMP9MMP3MMP13MMP7 | |
| SCHEMBL14878484 | 0.83 | MMP3 (0.44) | MMP1MMP9MMP3MMP13MMP7 | |
| SCHEMBL12905352 | 0.82 | MMP1 (0.43) | MMP1MMP9MMP3MMP13MMP7 | |
| SCHEMBL14878465 | 0.82 | MMP9 (0.41) | MMP1MMP9MMP3MMP13MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511488-B1 | HUMAN ADAM-10 INHIBITORS | SYMPHONY EVOLUTION INC (US) | 2013-05-22 | — | — | EP | disclosed |
| US-8426415-B2 | Human ADAM-10 inhibitors | SYMPHONY EVOLUTION, INC. (US) | 2013-04-23 | — | — | US | disclosed |
| EP-2436676-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-04-04 | — | — | EP | disclosed |
| EP-2428509-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |