Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.41 |
| ▸ | MMP9 | P14780 | 4/20 | 0.41 |
| ▸ | MMP13 | P45452 | 4/20 | 0.41 |
| ▸ | MMP3 | P08254 | 4/20 | 0.41 |
| ▸ | MMP7 | P09237 | 3/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12905437 | 0.91 | MMP1 (0.40) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL14878419 | 0.91 | MMP1 (0.53) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL778858 | 0.90 | MMP1 (0.53) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL14878420 | 0.89 | MMP1 (0.51) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL14878438 | 0.88 | CNR1 (0.38) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL14878393 | 0.84 | ALDH1A1 (0.36) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL14878439 | 0.84 | MMP3 (0.40) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL14878458 | 0.83 | MMP3 (0.49) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL12905490 | 0.83 | MMP1 (0.51) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL14878400 | 0.82 | LMNA (0.43) | MMP1MMP9MMP13MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426415-B2 | Human ADAM-10 inhibitors | SYMPHONY EVOLUTION, INC. (US) | 2013-04-23 | — | — | US | disclosed |
| EP-2436676-A1 | Human adam-10 inhibitors | Symphony Evolution, Inc. (US) | 2012-04-04 | — | — | EP | disclosed |