Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | ASPH | Q12797 | 4/20 | 0.59 |
| ▸ | KDM8 | Q8N371 | 4/20 | 0.59 |
| ▸ | RIOX2 | Q8IUF8 | 3/20 | 0.59 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | KDM5C | P41229 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6761973 | 0.85 | KDM4E (0.57) | KDM4EASPHKDM8RIOX2EGLN1 | |
| SCHEMBL23337477 | 0.74 | ACVRL1 (0.55) | KDM4EASPHKDM8EGLN1L3MBTL1 | |
| SCHEMBL28823850 | 0.74 | HPGD (0.53) | KDM4EKMT2AHDAC1 | |
| SCHEMBL14875866 | 0.72 | HDAC6 (0.54) | HDAC1 | |
| SCHEMBL31580871 | 0.72 | KCNK3 (0.52) | MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL2126506 | 0.72 | F2 (0.71) | KDM4EHTR7L3MBTL1KDM6BKDM4C | |
| SCHEMBL608754 | 0.72 | NOX4 (0.61) | KDM4EASPHKDM8RIOX2L3MBTL1 | |
| SCHEMBL18135105 | 0.71 | KDR (0.48) | KDM4EASPHKDM8LMNAHTT | |
| SCHEMBL5521631 | 0.71 | KDM4E (0.52) | KDM4EASPHKDM8RIOX2EGLN1 | |
| SCHEMBL11259354 | 0.71 | L3MBTL1 (0.63) | L3MBTL1KDM6BKDM4CMCL1BCL2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794616-A1 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013057253-A1 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-25 | — | — | WO | disclosed |