Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14889138 | 0.99 | TSPO (0.43) | TSPONPC1RAB9AHDAC1GABRA2 | |
| SCHEMBL14889133 | 0.92 | TSPO (0.52) | TSPOGABRA2GABRB2 | |
| SCHEMBL30589255 | 0.92 | TSPO (0.52) | TSPOGABRA2GABRB2 | |
| Hydrochloric Acid SCHEMBL14889244 | 0.91 | TSPO (0.51) | TSPOGABRA2GABRB2 | |
| SCHEMBL14889211 | 0.91 | TSPO (0.45) | TSPONPC1RAB9AHDAC1GABRA2 | |
| SCHEMBL30589252 | 0.91 | TSPO (0.45) | TSPONPC1RAB9AHDAC1GABRA2 | |
| Hydrochloric Acid SCHEMBL14889118 | 0.90 | TSPO (0.44) | TSPONPC1RAB9AHDAC1GABRA2 | |
| SCHEMBL30589259 | 0.89 | TSPO (0.46) | TSPONPC1RAB9AGABRA2GABRB2 | |
| SCHEMBL14889119 | 0.89 | TSPO (0.46) | TSPONPC1RAB9AGABRA2GABRB2 | |
| SCHEMBL15158408 | 0.89 | TSPO (0.47) | TSPONPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293537-A1 | USE OF ACETAMIDE DERIVATIVE IN PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE | ACADEMY OF MILITARY MEDICAL SCIENCES (CN) | 2023-09-21 | — | — | US | claimed |
| US-20230293537-A1 | USE OF ACETAMIDE DERIVATIVE IN PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE | ACADEMY OF MILITARY MEDICAL SCIENCES (CN) | 2023-09-21 | — | — | US | disclosed |
| US-20230293537-A1 | USE OF ACETAMIDE DERIVATIVE IN PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE | ACADEMY OF MILITARY MEDICAL SCIENCES (CN) | 2023-09-21 | — | — | US | disclosed |
| US-20230293537-A1 | USE OF ACETAMIDE DERIVATIVE IN PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE | ACADEMY OF MILITARY MEDICAL SCIENCES (CN) | 2023-09-21 | — | — | US | disclosed |
| EP-2586780-B1 | 2-ARYL IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE DERIVATIVES, PREPARATION METHODS AND USE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACAD MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2017-03-22 | — | — | EP | disclosed |
| US-8980887-B2 | 2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof | INSTITUTE OF PHARMACOLOGY (CN) | 2015-03-17 | — | — | US | disclosed |
| US-8980887-B2 | 2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof | INSTITUTE OF PHARMACOLOGY (CN) | 2015-03-17 | — | — | US | disclosed |
| US-20130203754-A1 | 2-Aryl Imidazo[1,2-a]Pyridine-3-Acetamide Derivatives, Preparation Methods and Uses Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-08-08 | — | — | US | disclosed |
| US-20130203754-A1 | 2-Aryl Imidazo[1,2-a]Pyridine-3-Acetamide Derivatives, Preparation Methods and Uses Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2013-08-08 | — | — | US | disclosed |
| EP-2586780-A1 | 2-ARYL IMIDAZO[1,2-A]PYRIDINE-3-ACETAMIDE DERIVATIVES, PREPARATION METHODS AND USE THEREOF | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China (CN) | 2013-05-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230293537-A1 | USE OF ACETAMIDE DERIVATIVE IN PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE | ACHE, APP, NAAA | TSPO 1344/4885NPC1 795/4885RAB9A 3787/4885 |
| US-20130203754-A1 | 2-Aryl Imidazo[1,2-a]Pyridine-3-Acetamide Derivatives, Preparation Methods and Uses Thereof | TSPO, SLC6A1, TBXA2R | TSPO 1/4885NPC1 780/4885RAB9A 2262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.