Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 12/20 | 0.40 |
| ▸ | BRD4 | O60885 | 4/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.40 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899776 | 0.87 | ADRA2C (0.48) | LMNAPOLBKMT2ASMN1; SMN2BRD9 | |
| SCHEMBL11944591 | 0.86 | MAPT (0.38) | NCF1LMNABRD9BRD4BRPF1 | |
| SCHEMBL11944571 | 0.77 | MAPT (0.39) | SMN1; SMN2 | |
| SCHEMBL14899753 | 0.77 | SMN1; SMN2 (0.48) | LMNAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL14899749 | 0.76 | SMN1; SMN2 (0.45) | LMNAPOLBKMT2ASMN1; SMN2HRH4 | |
| SCHEMBL17057799 | 0.76 | SMN1; SMN2 (0.39) | KMT2ASMN1; SMN2HTR1A | |
| SCHEMBL17058354 | 0.74 | MCHR1 (0.38) | LMNAPOLBKMT2ASMN1; SMN2HRH4 | |
| SCHEMBL14899737 | 0.74 | SMN1; SMN2 (0.46) | LMNAPOLBKMT2ASMN1; SMN2HRH4 | |
| SCHEMBL11944442 | 0.73 | CACNB4 (0.38) | LMNAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL17057760 | 0.73 | ATR (0.41) | LMNAPOLBKMT2ASMN1; SMN2BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |