Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899776 | 0.86 | ADRA2C (0.48) | SMN1; SMN2KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL17058354 | 0.86 | MCHR1 (0.38) | SMN1; SMN2MCHR1MEN1KMT2AADRA1A | |
| SCHEMBL11944442 | 0.84 | CACNB4 (0.38) | SMN1; SMN2MCHR1MEN1KMT2AUSP2 | |
| SCHEMBL17058087 | 0.83 | MCHR1 (0.34) | SMN1; SMN2MCHR1MEN1KMT2AADRA1A | |
| SCHEMBL17058267 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2KDM4EMCHR1KMT2AGAA | |
| SCHEMBL11944450 | 0.79 | MAPT (0.42) | SMN1; SMN2 | |
| SCHEMBL14081346 | 0.79 | NPC1 (0.32) | SMN1; SMN2MEN1KMT2AUSP2GAA | |
| SCHEMBL14899736 | 0.76 | NCF1 (0.50) | SMN1; SMN2KMT2AHTR1A | |
| SCHEMBL11944591 | 0.75 | MAPT (0.38) | MCHR1USP2 | |
| SCHEMBL11944557 | 0.73 | GPR6 (0.38) | SMN1; SMN2MCHR1MEN1KMT2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137179-B1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-09-02 | — | — | EP | disclosed |