Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969138 | 0.85 | NPC1 (0.49) | PTPN1CYP4F2CYP4A11SIRT2ALOX5 | |
| SCHEMBL30716575 | 0.84 | ALOX5 (0.51) | PTPN1ALOX5OR51E2ALDH1A1APP | |
| SCHEMBL1746504 | 0.84 | ALOX5 (0.51) | PTPN1ALOX5OR51E2ALDH1A1APP | |
| SCHEMBL13014917 | 0.83 | ALDH1A1 (0.53) | CYP4F2CYP4A11ALDH1A1NPC1RAB9A | |
| SCHEMBL2722156 | 0.83 | L3MBTL1 (0.43) | PTPN1SIRT2ALOX5OR51E2FFAR1 | |
| SCHEMBL1446362 | 0.83 | ALOX5 (0.50) | PTPN1ALOX5OR51E2FFAR1KMT2A | |
| SCHEMBL2722450 | 0.83 | CA12 (0.43) | PTPN1SIRT2ALOX5OR51E2FFAR1 | |
| SCHEMBL27972225 | 0.82 | APP (0.51) | PTPN1CYP4F2CYP4A11SIRT2ALOX5 | |
| SCHEMBL18830588 | 0.81 | FFAR1 (0.54) | FFAR1 | |
| SCHEMBL19403512 | 0.81 | NPC1 (0.49) | FFAR1ALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9717714-B2 | Spirocyclic CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-01 | — | — | US | disclosed |
| US-9346825-B2 | Fused bicyclic oxazolidinone CETP inhibitor | MERCK SHARP & DOHME CORP. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20150342931-A1 | SPIROCYCLIC CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-12-03 | — | — | US | disclosed |
| US-20140378493-A1 | Fused Bicyclic Oxazolidinone CETP Inhibitor | MERCK SHARP & DOHME LLC | 2014-12-25 | — | — | US | disclosed |
| US-8871738-B2 | Fused bicyclic oxazolidinone CETP inhibitor | MERCK SHARP & DOHME CORP. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20130109649-A1 | FUSED BICYCLIC OXAZOLIDINONE CETP INHIBITOR | MERCK SHARP & DOHME LLC | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378493-A1 | Fused Bicyclic Oxazolidinone CETP Inhibitor | CETP, MTTP, APOB | PTPN1 3153/4885CYP4F2 637/4885CYP4A11 431/4885 |
| US-20150342931-A1 | SPIROCYCLIC CETP INHIBITORS | CETP, MTTP, LCAT | PTPN1 3306/4885CYP4F2 1078/4885CYP4A11 516/4885 |
| US-20130109649-A1 | FUSED BICYCLIC OXAZOLIDINONE CETP INHIBITOR | CETP, MTTP, APOB | PTPN1 3153/4885CYP4F2 637/4885CYP4A11 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.