Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TPH1 | P17752 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15453430 | 0.85 | NR1H4 (0.62) | PPARANPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL13930853 | 0.83 | NR1H4 (0.61) | PPARANPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL28593073 | 0.77 | NR1H4 (0.78) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL3059321 | 0.77 | NR1H4 (0.78) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL16592595 | 0.76 | ACHE (0.57) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL11712234 | 0.75 | PPARA (0.49) | PPARANPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL28788077 | 0.75 | NPC1 (0.55) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL10670976 | 0.73 | PARP1 (0.50) | NPC1RAB9AUSP2ALDH1A1LMNA | |
| SCHEMBL13930818 | 0.73 | CASP3 (0.74) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL10495613 | 0.73 | NR1H4 (0.77) | NPC1RAB9ATP53SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10827753-B2 | Compositions and methods for controlling nematodes | MONSANTO TECHNOLOGY LLC (US) | 2020-11-10 | — | — | US | claimed |
| US-20190343120-A1 | COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODES | MONSANTO TECHNOLOGY LLC (US) | 2019-11-14 | — | — | US | claimed |
| US-20190208785-A1 | Composition and Methods for Reducing Nematodes | MONSANTO TECHNOLOGY LLC (US) | 2019-07-11 | — | — | US | claimed |
| US-9420788-B2 | Compositions and methods for controlling nematodes | MONSANTO TECHNOLOGY LLC (US) | 2016-08-23 | — | — | US | claimed |
| EP-2947080-A1 | COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODES | Monsanto Technology LLC (US) | 2015-11-25 | — | — | EP | claimed |
| US-20150150258-A1 | COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODES | MONSANTO TECHNOLOGY LLC (US) | 2015-06-04 | — | — | US | claimed |
| CN-104054719-A | Compositions And Methods For Controlling Nematodes | MONSANTO TECHNOLOGY LLC | 2014-09-24 | — | — | CN | claimed |
| US-8435999-B2 | Compositions and methods for controlling nematodes | MONSANTO TECHNOLOGY LLC (US) | 2013-05-07 | — | — | US | claimed |
| US-20190208785-A1 | Composition and Methods for Reducing Nematodes | MONSANTO TECHNOLOGY LLC (US) | 2019-07-11 | — | — | US | disclosed |
| WO-2017106715-A1 | COMPOSITION AND METHODS FOR REDUCING NEMATODES | MONSANTO TECHNOLOGY LLC (US) | 2017-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10827753-B2 | Compositions and methods for controlling nematodes | NOP2, ATL3, CYCS | PPARA 3010/4885NPC1 2871/4885RAB9A 3412/4885 |
| US-20190343120-A1 | COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODES | NOP2, ATL3, CYCS | PPARA 3010/4885NPC1 2871/4885RAB9A 3412/4885 |
| US-20150150258-A1 | COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODES | NOP2, ATL3, CYCS | PPARA 3010/4885NPC1 2871/4885RAB9A 3412/4885 |
| US-20190208785-A1 | Composition and Methods for Reducing Nematodes | RPL41, SPOUT1, MASTL | PPARA 4754/4885NPC1 3550/4885RAB9A 4191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.