Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.48 |
| ▸ | DBH | P09172 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30013888 | 0.81 | TDP1 (0.44) | ALDH1A1HSD17B10TDP1CDK2LMNA | |
| SCHEMBL1345089 | 0.81 | TDP1 (0.52) | ALDH1A1HSD17B10TDP1CDK2LMNA | |
| SCHEMBL1491236 | 0.81 | TDP1 (0.44) | ALDH1A1HSD17B10TDP1CDK2LMNA | |
| SCHEMBL27812266 | 0.80 | ACLY (0.42) | ALDH1A1TDP1CDK2CA1CA2 | |
| SCHEMBL11413280 | 0.80 | CDK2 (0.44) | ALDH1A1HSD17B10TDP1CDK2LMNA | |
| SCHEMBL29470806 | 0.79 | CDK2 (0.50) | ALDH1A1HSD17B10TDP1CDK2LMNA | |
| SCHEMBL114040 | 0.79 | CDK2 (0.50) | ALDH1A1HSD17B10TDP1CDK2LMNA | |
| SCHEMBL5518503 | 0.79 | CDK2 (0.63) | ALDH1A1HSD17B10TDP1CDK2LMNA | |
| SCHEMBL899804 | 0.78 | CDK2 (0.68) | ALDH1A1HSD17B10TDP1CDK2LMNA | |
| SCHEMBL29799756 | 0.78 | CDK2 (0.42) | ALDH1A1HSD17B10TDP1CDK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9808527-B2 | Methods and compositions for treating HIV infections | PURDUE RESEARCH FOUNDATION (US) | 2017-11-07 | — | — | US | disclosed |
| EP-2491785-A1 | Method and compositions for treating HIV infections | Purdue Research Foundation (US) | 2012-08-29 | — | — | EP | disclosed |
| US-7897635-B2 | HIV protease inhibitors | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2011-03-01 | — | — | US | disclosed |
| US-20100113582-A1 | METHODS AND COMPOSITIONS FOR TREATING HIV INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-05-06 | — | — | US | disclosed |
| EP-2120562-A2 | METHOD AND COMPOSITIONS FOR TREATING HIV INFECTIONS | Purdue Research Foundation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008133734-A2 | METHOD AND COMPOSITIONS FOR TREATING HIV INFECTIONS | PURDUE RESEARCH FOUNDATION (US) | 2008-11-06 | — | — | WO | disclosed |
| US-20070082883-A1 | HIV protease inhibitors | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-04-12 | — | — | US | disclosed |
| US-7157489-B2 | HIV protease inhibitors | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-01-02 | — | — | US | disclosed |
| EP-1485387-A1 | CARBAMATES AS HIV PROTEASE INHIBITORS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2004-12-15 | — | — | EP | disclosed |
| US-20040039016-A1 | HIV protease inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-02-26 | — | — | US | disclosed |
| WO-2003078438-A1 | CARBAMATES AS HIV PROTEASE INHIBITORS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2003-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082883-A1 | HIV protease inhibitors | SERPINB1, TMPRSS15, DNPEP | ALDH1A1 2558/4885HSD17B10 1076/4885TDP1 478/4885 |
| US-20040039016-A1 | HIV protease inhibitors | SERPINB1, TMPRSS15, DNPEP | ALDH1A1 2558/4885HSD17B10 1076/4885TDP1 478/4885 |
| US-20100113582-A1 | METHODS AND COMPOSITIONS FOR TREATING HIV INFECTIONS | SERPINB1, HPN, PRSS1 | ALDH1A1 2856/4885HSD17B10 533/4885TDP1 2446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.