Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.33 |
| ▸ | ESR1 | P03372 | 5/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 2/20 | 0.32 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491295 | 0.84 | ENPP2 (0.41) | ENPP2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL7815237 | 0.78 | ESR1 (0.37) | ENPP2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL29913593 | 0.69 | POLB (0.55) | ENPP2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL27919360 | 0.69 | POLB (0.55) | ENPP2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL7818433 | 0.67 | FGFR1 (0.38) | ENPP2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL28566722 | 0.65 | KDM4E (0.38) | ENPP2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL16863946 | 0.61 | PKM (0.58) | ENPP2KDM4EALDH1A1HPGDFGFR1 | |
| SCHEMBL6601753 | 0.61 | HTT (0.44) | ENPP2KDM4EALDH1A1HPGDESR2 | |
| SCHEMBL3192611 | 0.60 | KEAP1 (0.53) | HPGDMEN1USP2KMT2AKEAP1 | |
| SCHEMBL4081614 | 0.60 | DYRK1A (0.51) | ALDH1A1KMT2AESR1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011029832-A1 | NOVEL THIAZOL AND OXAZOL HEPCIDINE ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2011-03-17 | — | — | WO | disclosed |