SCHEMBL1491472

SCHEMBL1491472

O=C(O)[C@@H](NS(=O)(=O)c1ccc([N+](=O)[O-])cc1)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A3 P43003 1/20 0.59
SLC1A2 P43004 1/20 0.59
SLC1A1 P43005 1/20 0.59
MMP2 P08253 5/20 0.56
MMP9 P14780 3/20 0.56
MMP1 P03956 2/20 0.56
MMP13 P45452 2/20 0.56
MMP3 P08254 1/20 0.56
MMP7 P09237 1/20 0.56
KMT2A Q03164 3/20 0.54
CA2 P00918 5/20 0.54
CA12 O43570 4/20 0.54
CA9 Q16790 4/20 0.54
CA14 Q9ULX7 3/20 0.54
CA1 P00915 3/20 0.51
MMP8 P22894 1/20 0.51
SMN1; SMN2 Q16637 3/20 0.50
GAA P10253 2/20 0.50
ALDH1A1 P00352 2/20 0.50
L3MBTL1 Q9Y468 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1491474 1.00 SLC1A3 (0.59) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL4832393 0.88 MMP9 (0.68) MMP2MMP9KMT2ACA2CA12
SCHEMBL10102615 0.85 SLC1A3 (0.56) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL2053891 0.85 SLC1A3 (0.56) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL7025505 0.83 GFER (0.54) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL6610112 0.82 SLC1A3 (0.55) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL6923978 0.82 CA2 (0.59) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL31477053 0.81 MMP9 (0.69) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL1000596 0.81 ALDH1A1 (0.62) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL2161085 0.81 ALDH1A1 (0.62) SLC1A3SLC1A2SLC1A1MMP2MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250289810-A1 Compounds As NLRP3 Inflammasome Inhibitors And Their Use As Medicaments MAM-AGE S.R.L. (IT) 2025-09-18 US disclosed
WO-2023209109-A1 COMPOUNDS AS NLRP3 INFLAMMASOME INHIBITORS AND THEIR USE AS MEDICAMENTS MAM - AGE S.R.L. (IT) 2023-11-02 WO disclosed
US-9133104-B2 Enzyme inhibitors CHROMA THERAPEUTICS LTD. (GB) 2015-09-15 US disclosed
US-9133104-B2 Enzyme inhibitors CHROMA THERAPEUTICS LTD. (GB) 2015-09-15 US disclosed
US-20140163042-A1 ENZYME INHIBITORS CHROMA THERAPEUTICS LTD. (GB) 2014-06-12 US disclosed
US-20140163042-A1 ENZYME INHIBITORS CHROMA THERAPEUTICS LTD. (GB) 2014-06-12 US disclosed
US-20140163042-A1 ENZYME INHIBITORS CHROMA THERAPEUTICS LTD. (GB) 2014-06-12 US disclosed
US-20130116318-A1 Enzyme Inhibitors CHROMA THERAPEUTICS LTD. (GB) 2013-05-09 US disclosed
US-20130116318-A1 Enzyme Inhibitors CHROMA THERAPEUTICS LTD. (GB) 2013-05-09 US disclosed
US-20130116318-A1 Enzyme Inhibitors CHROMA THERAPEUTICS LTD. (GB) 2013-05-09 US disclosed
US-7939666-B2 Enzyme inhibitors CHROMA THERAPEUTICS LTD. (GB) 2011-05-10 US disclosed
US-7939666-B2 Enzyme inhibitors CHROMA THERAPEUTICS LTD. (GB) 2011-05-10 US disclosed
US-7939666-B2 Enzyme inhibitors CHROMA THERAPEUTICS LTD. (GB) 2011-05-10 US disclosed
EP-2301939-A1 Enzyme inhibitors Chroma Therapeutics Limited (GB) 2011-03-30 EP disclosed
EP-2301939-A1 Enzyme inhibitors Chroma Therapeutics Limited (GB) 2011-03-30 EP disclosed
US-20090291978-A1 Enzyme Inhibitors CHROMA THERAPEUTICS LTD. (GB) 2009-11-26 US disclosed
US-20090291978-A1 Enzyme Inhibitors CHROMA THERAPEUTICS LTD. (GB) 2009-11-26 US disclosed
US-20090291978-A1 Enzyme Inhibitors CHROMA THERAPEUTICS LTD. (GB) 2009-11-26 US disclosed
EP-1879895-A1 ENZYME INHIBITORS Chroma Therapeutics Limited (GB) 2008-01-23 EP disclosed
WO-2006117549-A1 ENZYME INHIBITORS CHROMA THERAPEUTICS LTD (GB) 2006-11-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130116318-A1 Enzyme Inhibitors HDAC1, HDAC11, HDAC7 SLC1A3 3986/4885SLC1A2 4025/4885SLC1A1 3841/4885
US-20250289810-A1 Compounds As NLRP3 Inflammasome Inhibitors And Their Use As Medicaments NLRP3, NLRP1, IL18 SLC1A3 655/4885SLC1A2 1375/4885SLC1A1 614/4885
US-20140163042-A1 ENZYME INHIBITORS HAT1, NR2E1, HDAC3 SLC1A3 1775/4885SLC1A2 2631/4885SLC1A1 1489/4885
US-20090291978-A1 Enzyme Inhibitors HAT1, NR2E1, NR2C2 SLC1A3 2843/4885SLC1A2 3524/4885SLC1A1 2770/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.