Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918896 | 0.89 | MEN1 (0.41) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL14918924 | 0.89 | HDAC1 (0.48) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL14918747 | 0.87 | HDAC6 (0.48) | MAPTMEN1KMT2AHDAC1HDAC8 | |
| SCHEMBL14918889 | 0.86 | MEN1 (0.38) | SMN1; SMN2MAPTTP53MEN1KMT2A | |
| SCHEMBL14919184 | 0.85 | L3MBTL1 (0.57) | SMN1; SMN2MAPTTP53NPC1RAB9A | |
| SCHEMBL14918545 | 0.84 | L3MBTL1 (0.56) | SMN1; SMN2MAPTTP53MEN1KMT2A | |
| SCHEMBL14918539 | 0.84 | L3MBTL1 (0.56) | SMN1; SMN2MAPTTP53MEN1KMT2A | |
| SCHEMBL14918439 | 0.84 | L3MBTL1 (0.56) | SMN1; SMN2MAPTTP53MEN1KMT2A | |
| SCHEMBL14919092 | 0.83 | L3MBTL1 (0.55) | SMN1; SMN2MAPTTP53NPC1RAB9A | |
| SCHEMBL14918730 | 0.82 | HDAC6 (0.40) | HDAC1HDAC8LMNAHTTHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |